The effect of eight weeks combined exercise training and coenzyme Q10 supplementation on motor function in patients with multiple sclerosis

Ahmadi, Amin and Haghighi, Amir Hossein and Nikkhah, Karim and Askari, Roya (2018) The effect of eight weeks combined exercise training and coenzyme Q10 supplementation on motor function in patients with multiple sclerosis. medical journal of mashhad university of medical sciences, 61 (2). pp. 958-970.

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Abstract

Introduction: The motor function in patients with multiple sclerosis is restricted and doing exercise training and supplementation with coenzyme Q10 can be effective in improving this condition. The purpose of this research was to investigate the effect of 8 weeks of combined exercise training and supplementation of coenzyme Q10 on some motor function indexes in patients with multiple sclerosis. Materials and Methods: In this semi-experimental study, 28 patients (16 men and 12 women; mean age = 37/71±7/18 years) with multiple sclerosis (EDSS=3-5) were selected using purposive sampling method and were evaluated into three experimental groups (combined exercise training+Q10 supplement, combined exercise training+placebo, Q10 supplement) and one control (placebo) group. The exercise training was done for 8 weeks (two sessions of resistance and one endurance session per week) and the dose of supplement of Q10 was 200 mg daily. Before and after intervention, the patients performed functional tests. Data were analyzed by statistical methods of covariance analysis, paired sample t-test and Bonferroni post-hoc test at a significant level of P <0.05. Results: The results of tests of analysis of covariance and paired sample t-test indicated significant reductions in the durations of functional tests of 25-foot walk and timed up and go and significant increases in the records of tests of chair stand and 6 minute walk in the training+supplement and training groups compared to the supplement and control groups after the end of the intervention period (P= 0.0001); but there was no significant difference between the two training groups (P ≥ 0.05). Conclusion: Accordingly, the patients with multiple sclerosis can use the provided combined training, with or without coenzyme Q10 supplementation, to improve their motor function. Also, coenzyme Q10 supplementation doesn't affect the improvement of motor function in these patients.

Item Type: Article
Subjects: WA Public Health
Depositing User: mjmums mjmums
Date Deposited: 27 Sep 2018 05:53
Last Modified: 27 Sep 2018 05:53
URI: http://eprints.mums.ac.ir/id/eprint/10348

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