In vivo effects of allogeneic mesenchymal stem cells in a rat model of acute ischemic kidney injury

Havakhah, Shahrzad and Sankian, Mojtaba and Kazemzadeh, Gholam Hosein and sadri, kayvan and Bidkhori, Hamid Reza and Naderi-Meshkin, Hojjat and Ebrahimzadeh Bideskan, Alireza and Niazmand, Saeed and Bahrami, Ahmad Reza and khajavirad, Abolfazl (2018) In vivo effects of allogeneic mesenchymal stem cells in a rat model of acute ischemic kidney injury. Iranian Journal of Basic Medical Sciences, 21 (8). pp. 824-831.

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Abstract

Objective(s): Renal ischemia-reperfusion injury (IRI) as a severe condition of acute kidney injury (AKI) is the most common clinical problem with high mortality rates of 35-60 deaths in hospital. Mesenchymal stem cells (MSC) due to unique regenerative characteristics are ideal candidates for the treatment of the ischemic injuries. This work is focused on the administration of MSC to IRI-induced AKI Wistar rats and evaluating their significance in AKI treatment. Material and Methods: Animals underwent surgical procedure and AKI was induced by 40 min bilateral renal pedicle clamping. Immediately after reperfusion, 2×106 rat bone marrow derived MSCs were injected via intra-parenchymal or intra-aortic route. Results: Animals subjected to AKI after days 1 and 3 showed significant increase in the serum creatinine and blood urea nitrogen (BUN) concentration along with a declined glomerular filtration rate (GFR) when compared with non-ischemic animals. On the other hand, treated animals showed a significant enhanced regeneration as compared to ischemic animals in both administration route groups. Conclusion: According to the results concluded from the renoprotective effects of MSC in IRI/AKI, MSCs could be considered as promising therapeutic approach for AKI in clinical applications.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 02 Oct 2018 09:18
Last Modified: 02 Oct 2018 09:18
URI: http://eprints.mums.ac.ir/id/eprint/10479

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