Expression of Transforming Growth Factor Beta in Giant-cell Granuloma of Jaws and Giant-cell Tumor of Bone

Saghravanian, Nasrollah and Jafarian, Amir hossein and Ghazi, Narges and Mozayeni, Moein (2018) Expression of Transforming Growth Factor Beta in Giant-cell Granuloma of Jaws and Giant-cell Tumor of Bone. Journal of Mashhad Dental School, 42 (3). pp. 228-221.

[img] Text
JMDS_Volume 42_Issue 3_Pages 228-221.pdf

Download (664kB)
Official URL: http://jmds.mums.ac.ir/article_11458.html

Abstract

Background and Objectives: Peripheral and central giant-cell granulomas (PGCGs and CGCGs) and giant-cell tumor (GCT) of bone have similar histopathological features with different biological behavior. The aim of this study was to evaluate the expression of transforming growth factor beta (TGF-β) in these lesions by the help of immunohistochemistry. Materials and Methods: In this study, 15 PGCGs, 15 CGCGs, and 10 GCTs were evaluated. The TGF-β immunoreactivity was assessed in mononuclear cells (MC) and multinucleated giant cells (MGC) of the studied groups. Data analysis was performed using Kruskal-Wallis and Dunn’s tests. Results: There was a significant difference between three studied groups regarding both MCs and MGCs. The highest mean of TGF-β immunostaining was observed in GCTs and the lowest in PGCGs. In pairwise comparison of the studied groups, a significant difference was observed between PGCGs and GCTs considering both MCs and MGCs. Additionally, a significant deference was reported only in MCs between CGCGs and GCTs. Conclusion: The results may explain the different biological behavior and pathogenesis of these lesions despite the similarity of histopathologic features.

Item Type: Article
Subjects: WU Dentistry. Oral surgery
Divisions: Journals > Journal of Mashhad Dental School
Depositing User: jmds jmds
Date Deposited: 10 Oct 2018 06:56
Last Modified: 10 Oct 2018 06:56
URI: http://eprints.mums.ac.ir/id/eprint/10502

Actions (login required)

View Item View Item