Comparison of Anti-Fungal Effect of Origanum Vulgare Extract Versus Nystatin On Candida Albicans; an In Vitro Study

Movaghari Pour, Ateke and Sheikh Fathollahi, Mahmood and Poor Zamani, Mahsa and Abedini, Shirin and Jamali, Zahra (2018) Comparison of Anti-Fungal Effect of Origanum Vulgare Extract Versus Nystatin On Candida Albicans; an In Vitro Study. Journal of Mashhad Dental School, 42 (3). pp. 277-271.

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Abstract

Introduction: Oral infections caused by Candida species are increasing widely. Nystatin is one of common topical medications used in the treatment of these oral lesions, which shows anti-fungal and antimicrobial activities. Common anti-fungal drugs show various side effects and result in drug resistance, as well as frequent recurrence. Thus, trying to find an alternative for synthetic drugs that do not have these disadvantages is valuable. This in-vitro study was aimed at comparing antifungal effects of Organum vulgare extract with nystatin on Candida albicans. Materials and Methods: In this in-vitro study, aqueous and alcoholic extracts of Origanum vulgare were prepared in concentrations of 10, 20, 40, 80 and 100. Candida albicans was cultured on Sabouraud Dextrose Agar. Within each plate, one disc containing any of the concentrations using plant extracts, a nystatin disc as positive control, and a disk containing distilled water as negative control were placed. After 24 h, the mean diameter of non-growth halo of different concentrations and nystatin were compared using One-way ANOVA or independent two samples t-test. Results: The mean diameter of non-growth halo around the discs containing aqueous and alcoholic extracts of Organum vulgare were significantly lower than that of nystatin in all the concentrations (P<0.001). Conclusion: Antifungal effect of nystatin on Candida albicans was more than that of aqueous and alcoholic extracts of Organum vulgare.

Item Type: Article
Subjects: WU Dentistry. Oral surgery
Divisions: Journals > Journal of Mashhad Dental School
Depositing User: jmds jmds
Date Deposited: 10 Oct 2018 06:50
Last Modified: 10 Oct 2018 06:50
URI: http://eprints.mums.ac.ir/id/eprint/10507

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