Correlation between Human Herpes virus 8 (HHV8-) and Plasma Cell Myeloma: a Systematic Review

Sadeghian, Mohammad Hadi and Rezaei Dezaki, Zahra and Shams, Seyyede Fatemeh and Shakeri, Sepideh (2018) Correlation between Human Herpes virus 8 (HHV8-) and Plasma Cell Myeloma: a Systematic Review. Reviews in Clinical Medicine, 5 (3). pp. 95-100.

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Introduction: Plasma cell myeloma is the distortion of differentiated B lymphocytes which is associated with uncontrolled proliferation of plasma cells in bone marrow. Some studies propound a role for HHV-8 virus in pathogenesis of plasma cell myeloma. Yet the findings are inconsistent. In this article we reviewed the literatures to determine the HHV-8 virus role in plasma cell myeloma pathogenesis.Methods: In this systematic review, scientific databanks including PubMed, Scopus, Embase, ISI, and Google scholar were searched. The search was based on the subsequent keywords and medical terms in title; different combinations of keywords were used, they were compatible with MeSH terms.Result: Four articles declared that there is no link between the HHV-8 and the pathogenesis of plasma cell myeloma; while five reported a connection between the virus and myeloma, arguing that virus infection will lead to disease progression.Conclusion: There are differences between the results of the studies. It is required to do further researches about the association of HHV-8 and plasma cell myeloma.

Item Type: Article
Subjects: WH Hemic and Lymphatic System
Divisions: Journals > Reviews in Clinical Medicine
Depositing User: RCM RCM
Date Deposited: 23 Oct 2018 09:32
Last Modified: 23 Oct 2018 09:32

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