Comparison of the Effects of Ondansetron, Vitamin B6 and Ginger Rhizome in Nausea and Vomiting of Pregnancy: A randomized clinical trial

Nazari, Sasan and Nazari, Saman and Shayan, Arezoo and Shobeiri, Fatemeh and Ahmadi Nia Tabesh, Roya (2018) Comparison of the Effects of Ondansetron, Vitamin B6 and Ginger Rhizome in Nausea and Vomiting of Pregnancy: A randomized clinical trial. The Iranian Journal of Obstetrics, Gynecology and Infertility, 21 (7). pp. 29-35.

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Abstract

Introduction: Nausea and vomiting is one of common complications in pregnancy that not only affects the women's physical health, it can also have a negative impact on their psychological and social performance. Suggestions have been made to effect on the nausea and vomiting of pregnancy. There are different methods to control the nausea and vomiting of pregnancy. Therefore, this study was performed with aim to compare the effect of Ondansetron, Vitamin B6 and Ginger Rhizome on nausea and vomiting in pregnancy. Methods: This double-blinded randomized clinical trial was performed on 120 pregnant women with gestational age <16 weeks who had mild and moderate nausea and vomiting referred to health centers of Hamadan in 2017. The samples were randomly divided in four groups of 30 cases: Ondansetron (4 mg), Vitamin B6 (40 mg), Ginger Rhizome (250 mg), and placebo groups, two times per day for one week. Severity of nausea and vomiting was assessed before and after the study by nausea and vomiting questionnaires (PUQE). Data was analyzed by SPSS software (version 21) and using chi-square, paired t-tests and ANOVA. P <0.05 was considered significant. Results: before the intervention, no significant difference was found in the four groups in the score of pregnancy nausea and vomiting (p=1.00). After the intervention, according to ANOVA test, the score of nausea and vomiting was significantly different between the Ondansetron, Vitamin B6 and Ginger Rhizome groups with placebo group (p<0.001). According to paired t-test, severity and duration of nausea and vomiting was significantly reduced in three treatments groups (p<0.001), and this decrease was less and significant in the ginger root group (P<0.001). Conclusion: Ginger Rhizome like as Ondansetron and vitamin B6 can reduce the severity and duration of nausea and vomiting; therefore its use in pregnant women can be helpful.

Item Type: Article
Subjects: WP Gynecology
WQ Obstetrics
Divisions: Journals > Iranian J Obstetrics, Gynecology and Infertility
Depositing User: ijogi ijogi
Date Deposited: 08 Dec 2018 08:54
Last Modified: 08 Dec 2018 08:54
URI: http://eprints.mums.ac.ir/id/eprint/10559

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