Protective effects of long-term administration of Ziziphus jujuba fruit extract on cardiovascular responses in L-NAME hypertensive rats

Mohebbati, Reza and Bavarsad, Kosar and Rahimi, Maryam and Rakhshandeh, Hasan and Khajavirad, Abolfazl and Shafei, Mohammad Naser (2018) Protective effects of long-term administration of Ziziphus jujuba fruit extract on cardiovascular responses in L-NAME hypertensive rats. Avicenna Journal of Phytomedicine, 8 (2). pp. 143-151.

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Abstract

Objective: Ziziphus jujuba stimulates the release of nitric oxide (NO). Because NO is involved in cardiovascular regulations, in this study the effects of hydroalcoholic extract of Z. jujuba on cardiovascular responses in acute NG-nitro-L-arginine methyl ester (L-NAME) hypertensive rats were evaluated. Materials and Methods: Rats were divided into 6 group (n=6): 1) saline, 2) L-NAME received (10mg/kg) intravenously, 3) sodium nitroprusside (SNP) (50µg/kg)+L-NAME group received SNP before L-NAME and 4-6) three groups of Z. jujuba (100, 200 and 400mg/kg) that treated for four weeks and on the 28th day, L-NAME was injected. Femoral artery and vein were cannulated for recording cardiovascular responses and drug injection, respectively. Systolic blood pressure (SBP), Mean arterial pressure (MAP) and heart rate (HR) were recorded continuously. Maximal changes (�) of SBP, MAP and HR were calculated and compared to control and L-NAME groups. Results: In L-NAME group, maximal �SBP (L-NAME: 44.15±4.0 mmHg vs control: 0.71±2.1 mmHg) and �MAP (L-NAME: 40.8±4.0 mmHg vs control: 0.57±1.6 mmHg) significantly increased (p0.05). All doses of Z. jujuba attenuated maximal �SBP and �MAP induced by L-NAME but only the lowest dose (100 mg/kg) had significant effects (�SBP: 20.36±5.6 mmHg vs L-NAME: 44.1±4.0 mmHg and �MAP: 20.8±4.5 mmHg vs L-NAME: 40.8±3.8 mmHg (p0.05). Conclusion: Because long-term consumption of Z. jujuba extract, especially its lowest dose, attenuated cardiovascular responses induced by L-NAME, we suggest that Z. jujuba has potential beneficial effects in prevention of hypertension induced by NO deficiency.

Item Type: Article
Subjects: WG Cardiovascular System
QT physiology
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 26 Dec 2018 09:37
Last Modified: 26 Dec 2018 09:37
URI: http://eprints.mums.ac.ir/id/eprint/10704

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