Effects of IMOD� on angiogenesis, miR-503 and CDC25 expression levels in heart tissue of diabetic male rats

Ghaffari-Nasab, Arshad and Mirzaei Bavil, Fariba and Ghiasi, Rafigheh and Sadigh-Eteghad, Saeed and Alipour, Mohammad Reza (2018) Effects of IMOD� on angiogenesis, miR-503 and CDC25 expression levels in heart tissue of diabetic male rats. Avicenna Journal of Phytomedicine, 8 (2). pp. 152-160.

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Abstract

Objective: Diabetes is associated with vascular complications and impaired angiogenesis. Since angiogenesis plays a crucial role in vascular homeostasis in ischemic heart diseases, in this study, the effect of IMOD� on miR-503 and CDC25 expression level which are altered in impaired angiogenesis were investigated in heart tissue of diabetic rats. Materials and Methods: Forty male Wistar rats (200-250 g) were randomly classified into 4 groups: control (C), IMOD� (I), diabetes (D), and diabetes+IMOD� (D+I). For induction of experimental diabetes in animals, a single dose of streptozotocin (STZ; 60mg/kg) was injected intraperitoneally. After 8 weeks of treatment with IMOD� (20 mg/kg/day), heart tissue samples were removed and used for measurement of miR-503 and CDC25 expression level as well as histological studies. Results: Results of this study showed that diabetes decreased heart tissue angiogenesis which was associated with increased miR-503 and reduced CDC25 expression levels (p<0.05) and IMOD� could reduce the expression of miR-503 and increase the expression of CDC25 (p<0.05). Moreover, IMOD� extensively induced angiogenesis in the heart tissue of diabetic group. However, IMOD� had no significant effect on expressions of miR-503 and CDC25, or angiogenesis in healthy rats. Conclusion: This study showed that IMOD� is able to increase angiogenesis in the heart tissue of diabetic rats. The angiogenic effect of IMOD� is associated with reduction of miR-503 expression and increased expression of CDC25.

Item Type: Article
Subjects: QT physiology
QU Biochemistry
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 26 Dec 2018 09:39
Last Modified: 26 Dec 2018 09:39
URI: http://eprints.mums.ac.ir/id/eprint/10705

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