Protective effect of Mumiju against acetic acid-induced ulcerative colitis in rats

Shahrokhi, Nadar and Keshavarzi, Zakieh and Khaksari Haddad, Mohammad and Amirafzali, Fereshteh and Dabiri, Shahriar and Shahrokhi, Nava (2018) Protective effect of Mumiju against acetic acid-induced ulcerative colitis in rats. Avicenna Journal of Phytomedicine, 8 (5). pp. 457-464.

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Objective: In this study, we elucidated the ameliorative effect of aqueous extract of leaves of Mumiju against acetic acid-induced experimental colitis in male rats. Materials and Methods: The animals were randomly divided into four groups (n=7) including I: control group, II: vehicle group (injected with 2 ml acetic acid (4) intra rectally), III and IV: treatment groups which received Mumiju (250 mg/kg) orally or intraperitoneally for 4 consecutive days after ulcer induction. Ulcer index, severity of inflammation, colonic levels of superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA), and histological changes were recorded after the treatment regimen of 4 days. Results: The ulcer index, severity of inflammation and colonic MDA levels were increased following intrarectal instillation of acetic acid. Also, acetic acid significantly decreased the SOD and GSH levels. Treatment with Mumiju for 4 days exhibited significantly lowered oxidative stress, while elevated of SOD and GSH levels. Regenerative-healing patterns also was seen by histopathological findings after treatment with Mumiju. Conclusion: The present investigation demonstrates that Mumiju could be regarded as a herb with potent therapeutic value in the amelioration of experimental colitis in laboratory animals by modulation of oxidant- antioxidant system.

Item Type: Article
Subjects: WI Digestive System
QT physiology
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 27 Dec 2018 04:43
Last Modified: 27 Dec 2018 04:43

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