Background-Based Delineation of Internal Tumor Volumes on Static Positron Emission Tomography in a Phantom Study

chen, yangchun and Chen, Xiangrong and Liu, Ji-an and Li, Fanyong (2016) Background-Based Delineation of Internal Tumor Volumes on Static Positron Emission Tomography in a Phantom Study. Asia Oceania Journal of Nuclear Medicine and Biology, 4 (1). pp. 38-44.

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Abstract

Objective(s): Considering the fact that the standardized uptake value (SUV) of a normal lung tissue is expressed as x±SD, x+3Ã�SD could be considered as the threshold value to outline the internal tumor volume (ITV) of a lung neoplasm. Methods: Three hollow models were filled with 55.0 kBq/mL fluorine18- fluorodeoxyglucose (18F-FDG) to represent tumors. The models were fixed to a barrel filled with 5.9 kBq/mL 18F-FDG to characterize normal lung tissues as a phantom. The PET/CT images of the phantom were acquired at rest. Then, the barrel was moved periodically to simulate breathing while acquiring PET/CT data. Volume recovery coefficient (VRC) was applied to evaluate the accuracy of ITVs. For statistical analysis, paired t-test and analysis of variance were applied. Results: The VRCs ranged from 0.74 to 0.98 and significantly varied among gross tumor volumes for delineating ITV (P<0.01). In two-dimensional PET scans, the motion distance did not affect VRC (P>0.05), whereas VRC decreased with increasing distance in three-dimensional PET scans (P<0.05). Conclusion: The threshold value (x+3Ã�SD) had the potential to delineate the ITV of cancerous tissues, surrounded by lung tissues, particularly in two-dimensional PET images.    Â

Item Type: Article
Subjects: WN Radiology . Diagnostic Imaging
Divisions: Journals > Asia Oceania J Nuclear Medicine & Biology
Depositing User: AOJNMB AOJNMB
Date Deposited: 19 Sep 2017 13:28
Last Modified: 19 Sep 2017 13:28
URI: http://eprints.mums.ac.ir/id/eprint/1078

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