Evaluation of Serum NT-Pro Brain Natriuretic Peptide Levels in Neonates with Respiratory Distress

Noori, Noor Mohammad and Yazdanparast, Amer and Nakhaee Moghaddam, Maryam and Teimouri, Alireza (2018) Evaluation of Serum NT-Pro Brain Natriuretic Peptide Levels in Neonates with Respiratory Distress. International Journal of Pediatrics, 6 (6). pp. 7769-7780.

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Abstract

Background Respiratory Distress (RD) is a life-threatening respiratory failure. This study aimed to evaluate the diagnostic value of N-terminal prohormone of brain natriuretic peptide (NT-pro-BNP) in distinguishing respiratory and heart diseases in neonates. Materials and Methods Hundred fifty neonates aged 2-3 days randomly collected from those who hospitalized in the related ward of the Ali Ebne Abitaleb Hospital, Zahedan, Iran. After sampling 2ml blood from venipuncture by trained nurse in the related ward separated serums performed in a laboratory. Then, 250 μl of the patients� serum was isolated to assess NT- pro-BNP level using ELISA kit (USA). Data were analyzed using SPSS software version 20.0 with considering of P< 0.05. Results Mean of NT-pro-BNP in respiratory, Acyanotic, cyanotic and controls were 386.22±208.82, 384.83±183.74, 372.23±143.04, and 161.70-± 121.2, respectively. Weight, height and head circumference had different mean ranks for respiratory, Acyanotic, cyanotic and healthy groups, respectively (P<0.05). Conclusion According to the results, despite of some reports, NT-proBNP is good biomarker to determine differentiate between cardiac and respiratory during neonate.

Item Type: Article
Subjects: WG Cardiovascular System
WS Pediatrics
QU Biochemistry
QY Clinical Pathology
Divisions: Journals > International J Pediatrics
Depositing User: IJP IJP
Date Deposited: 04 Jan 2019 09:12
Last Modified: 04 Jan 2019 09:13
URI: http://eprints.mums.ac.ir/id/eprint/10819

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