The Effect of Oral Fenofibrate on Serum Bilirubin Level in Term Neonates with Hyperbilirubinemia: A Randomized Clinical Trail

Ahmadpour-kacho, Mousa and Zahed Pasha, Yadollah and Moghadamnia, Ali Akbar and Khafri, Soryia and Vafaeinezhad, Maryam (2018) The Effect of Oral Fenofibrate on Serum Bilirubin Level in Term Neonates with Hyperbilirubinemia: A Randomized Clinical Trail. International Journal of Pediatrics, 6 (10). pp. 8317-8327.

[img] Text
IJP_Volume 6_Issue 10_Pages 8307-8316.pdf

Download (366kB)
Official URL: http://ijp.mums.ac.ir/article_10883.html

Abstract

Background Several agents have been used for the treatment of neonatal hyperbilirubinemia, but the effect of oral fenofibrate on serum bilirubin level was not evaluated so much. The aim of this study was to assess the effect of oral fenofibrate on a total serum bilirubin (TSB) in term neonates with hyperbilirubinemia. Materials and Methods: This clinical trial was done on 80 term neonate with a TSB higher than 15 mg/dl in two equal groups of control and intervention. Both groups received conventional phototherapy with the same condition. The intervention group received a single dose of oral Fenofibrate (Sobhan- Darou Company, Iran) 10 mg/kg. The TSB was measured in both groups, at admission, second day, and third day and also at the time of discharge. The serum bilirubin level, the duration of phototherapy and need to exchange transfusion were compared in two groups. Results: Results showed that of 80 neonates studied, the TSB at the second day of hospitalization in the intervention group was 13.29 ±1. 64 mg/dl and in control group 14.06±1.78 mg/dl (p=0.04), and at the third day in intervention group it was decreased to 9.99± 1.53 (p=0.04), and in control group to 11.01±1.68 mg/dl, (p=0.006). The duration of phototherapy in the intervention group was 2.5±0.71 days and in control group 3.35±0.97 days (p=0.003).  Conclusion According to the result of this study administration of oral Fenofibrte in a term neonate with hyperbilirubinemia under the phototherapy lead to faster decline in serum bilirubin levels, shorten the duration of hospital stay and earlier discharge from hospital.

Item Type: Article
Subjects: WA Public Health
WS Pediatrics
QY Clinical Pathology
Divisions: Journals > International J Pediatrics
Depositing User: IJP IJP
Date Deposited: 07 Jan 2019 10:53
Last Modified: 07 Jan 2019 10:53
URI: http://eprints.mums.ac.ir/id/eprint/10884

Actions (login required)

View Item View Item