Effects of Diesel Combustion Nanoparticles on Oxidative Stress Markers among the Exposures

Mahadeshwara Prasad, Devanur Rajashekhara Murthy and Kumar, Shashank and Malini, Suttur Srikantanaik and Shivanagappa, Manjula (2018) Effects of Diesel Combustion Nanoparticles on Oxidative Stress Markers among the Exposures. Asia Pacific Journal of Medical Toxicology, 7 (1). pp. 7-12.

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Background: Although studies are available on lipid peroxidation products and the antioxidant status in experimental animals, a detailed report on human exposed to diesel combustion nanoparticles is meagre. We aimed to study the variation in oxidative stress markers among exposures. Method:A cross-sectional study during the period between 2015-2017 was conducted among 500 male garage workers of age group 25-40 years with history of exposure for 6-8 hrs a day without using any protective aids during work, for 6-12 years and 300 controls, who live in hilly areas where they were sparsely exposed. Serum oxidative stress markers were estimated and compared. Â Results:A significant variation was observed among the oxidative stress markers in exposures with surge in melanaldehyde (MDA) and reduction in superoxide dismutase (SOD) and catalase (CAT). Conclusion:Unprotected exposure to diesel combustion products induces oxidative stress which can alter recordable change among the markers. Oxidative stress, being the route cause for cell damage, can be marked in the initial stages and is a good biomonitoring factor in primary care.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Asia Pacific J Toxicology
Depositing User: apjmt apjmt
Date Deposited: 05 Jan 2019 13:02
Last Modified: 05 Jan 2019 13:02
URI: http://eprints.mums.ac.ir/id/eprint/10930

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