Depression was associated with apolipoprotein E ε4 allele polymorphism: A meta-analysis

Wang, Wei-wei and Liu, Xiao-lei and Ruan, Ye and Wang, Lin and Bao, Tianhao (2019) Depression was associated with apolipoprotein E ε4 allele polymorphism: A meta-analysis. Iranian Journal of Basic Medical Sciences, 22 (2). pp. 112-117.

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Objective(s): Previous studies have reached different conclusions regarding an association between apolipoprotein E (APOE) polymorphisms and depression. This meta-analysis was designed to clarify these controversies. Materials and Methods: Literatures were identified reviewing the national and international databases. The eligible articles for meta-analysis were determined by quality assessment and implementation of inclusion/exclusion criteria. This meta-analysis was performed using Review Manager 5.2 software. The odds ratios (ORs) with corresponding 95 confidence interval (CIs) were calculated using a fixed effects model. Funnel plots and Egger’s regression tests were used to assess the publication bias. Results: A total of nine studies that met the inclusion criteria were identified by performing a comprehensive search on the association between APOE polymorphisms and depression. APOE ε4 allele was significantly associated with depression (allele: OR=1.36, 95CI=1.11-1.66, P=0.003; dominant: OR=1.34, 95CI=1.06-1.68, P=0.001; recessive: OR= 1.11, 95CI =0.45-2.76, P=0.82). HAMD scores were higher in depression patients with-APOE ε4 genotype than who without-APOE ε4 genotype (OR=0.96, 95CI=0.16-1.76, P=0.02). Conclusion: APOE ε4 allele increased the depression risk; depressive patients carrying APOE ε4 allele had more severe depressive symptoms.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 07 Jan 2019 09:30
Last Modified: 07 Jan 2019 09:30

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