Investigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is created

Yilmaz, Seher and Ülger, Harun and Ertekin, Tolga and Yay, Arzu and Nisari, Mehtap and Alpa, Şerife and Acer, Niyazi (2019) Investigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is created. Iranian Journal of Basic Medical Sciences, 22 (4). pp. 418-425.

[img] Text
IJBMS_Volume 22_Issue 4_Pages 418-425.pdf

Download (684kB)
Official URL: http://ijbms.mums.ac.ir/article_12271.html

Abstract

Objective(s): In this study, the effects of different doses of curcumin application on Ehrlich ascites tumor (EAT) created in the mice of BALB/c type were investigated.Materials and Methods: Curcumin extracts can have hindering effect on tumor volume, vascular density, EAT cells around the tissues, and can support apoptosis. EAT cells (1x106) received from stock animals were injected intraperitoneally (IP) and subcutaneously (SC) to the animals. Then, curcumin was administered IP. Doses of 25 mg/kg IP and 50 mg/kg were administered over 10 days to the animals in the treatment groups in which ascites tumor was induced. The same doses were administered over 15 days in the treatment groups in which solid tumor was induced.Results: Histopathological examination in ascites tumor groups revealed that number of EAT cells at surrounding tissues was smaller in the group received 50 mg/kg curcumin when compared to tumor control group (P<0.05). The lowest increase in tumor volume was observed in the group received 25 mg/kg curcumin when compared to tumor control group (P<0.05). Conclusion: It was demonstrated once again in our study that curcumin had an anti-tumoral effect on both the development of ascites tumor created through EAT cells and the development of solid tumor.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 10 Jun 2019 08:17
Last Modified: 10 Jun 2019 08:17
URI: http://eprints.mums.ac.ir/id/eprint/11262

Actions (login required)

View Item View Item