Molecular mechanisms regulating immune responses in thromboangiitis obliterans: a comprehensive review

Shapouri-Moghaddam, Abbas and Saeed modaghegh, Mohamad Hadi and Rahimi, Hamid reza and Ehteshamfar, Seyyed-Morteza and Tavakolafshari, Jalil (2019) Molecular mechanisms regulating immune responses in thromboangiitis obliterans: a comprehensive review. Iranian Journal of Basic Medical Sciences, 22 (3). pp. 215-224.

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Abstract

Thromboangiitis obliterans (TAO) is a thrombotic-occlusive as well as an inflammatory peripheral vascular disease with unknown etiology. Recent evidence has supported the immunopathogenesis of the disease, however, the factors contributing to the altered immune function and vascular tissue inflammation are still unclear. This review was intended to collate the more current knowledge on the regulatory molecules involved in TAO from an immunoreactive perspective. The homeostasis of the immune system as well as a variety of progenitor cell populations appear to be affected during TAO and these alterations are associated with intrinsic signaling defects that are directing to an improved understanding of the crosstalk between angiogenesis and the immune system, as well as the potential of new co-targeting strategies applying both immunotherapy and angiogenic therapy.

Item Type: Article
Subjects: QW Microbiology and Immunology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 10 Jun 2019 08:06
Last Modified: 10 Jun 2019 08:06
URI: http://eprints.mums.ac.ir/id/eprint/11268

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