Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A in rats

Alboghobeish, Soheila and Mahdavinia, Masoud and Zeidooni, Leila and Samimi, Azin and Oroojan, Ali Akbar and Alizadeh, Saeid and Dehghani, Mohammad Amin and Ahangarpour, Akram and Khorsandi, Layasadat (2019) Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A in rats. Iranian Journal of Basic Medical Sciences, 22 (3). pp. 315-323.

[img] Text
IJBMS_Volume 22_Issue 3_Pages 315-323.pdf

Download (642kB)
Official URL: http://ijbms.mums.ac.ir/article_12179.html

Abstract

Objective(s): Bisphenol A (BPA) as a synthetic compound is applied in many plastic industries. BPA has been reported to have endocrine-disrupting feature with cytotoxic effects. The study aimed to evaluate the efficiency of Naringin against testicular toxicity induced by BPA in adult rats.Materials and Methods: The animals were assigned into six groups of control, BPA-treated (50 mg/kg), BPA+Naringin-administrated (40, 80, 160 mg/kg) and Naringin-treated (160 mg/kg) for 30 days. At the end of experiments, testicular weight, total testicular protein, epididymal sperm count, testicular enzymes, serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone and estradiol, testicular enzymatic and non-enzymatic antioxidants and histopathology of testis tissue were evaluated by their own methods. Results: The results showed a reduction in testicular weight, total testicular protein, epididymal sperm count, testicular enzymes (alkaline phosphatase and lactate dehydrogenase) and decrease in the serum TSH, LH, testosterone and estradiol in BPA-administrated rats. Furthermore, BPA reduced the enzyme activities of glutathione peroxidase, superoxide dismutase, and catalase in testis tissue. Also, BPA caused an induction in lipid peroxidation and increase in reactive oxygen species levels, whereas it decreased the glutathione content of testis tissue. Histological findings exhibited seminiferous tubules vacuoles, atrophy and separation of the germinal epithelium in BPA-administrated rats. Oral administration of Naringin along with BPA normalized the biochemical, morphological and histological changes and reduced the testicular toxic condition. Conclusion: These results demonstrated that Naringin significantly managed male reproductive toxicity by antioxidant capabilities, preventing morphological modifications and escalating defense mechanism, thereby reducing oxidative stress from BPA-induced damage.

Item Type: Article
Subjects: QW Microbiology and Immunology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 10 Jun 2019 08:02
Last Modified: 10 Jun 2019 08:02
URI: http://eprints.mums.ac.ir/id/eprint/11281

Actions (login required)

View Item View Item