Serum 25-Hydroxy Vitamin D in Chronic Rhinosinusitis with and Without Nasal Polyposis: A Case-Control Study in Northern Iran

Faghih Habibi, Ali and Gerami, Hooshang and Banan, Rahmatollah and Kazemnejad, Ehsan and Khoshkhat, Parsa and Alaie, Hooman and Nemati, Shadman (2019) Serum 25-Hydroxy Vitamin D in Chronic Rhinosinusitis with and Without Nasal Polyposis: A Case-Control Study in Northern Iran. Iranian Journal of Otorhinolaryngology, 31 (1). pp. 19-24.

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Abstract

Introduction: Chronic rhinosinusitis (CRS) with and without nasal polyposis is a chronic inflammatory disease of the sinuses and nasal mucosa. Recent evidence has indicated a relationship between serum 25-hydroxyl vitamin D (OH-VitD) deficiency and CRS. Regarding this, the present study aimed to compare the serum level of 25-OH-VitD in CRS patients with and without nasal polyposis and control groups. Materials and Methods: This study was conducted on 117 adult subjects in three groups of CRS with nasal polyposis (CRSwNP; n=32), CRS without nasal polyposis (CRSsNP; n=35), and healthy controls (n=50). The mean level of serum 25-OH-VitD in the three groups was measured by means of enzyme- linked immunosorbent assay. The data were analyzed using SPSS software (version 18). Results: Mean serum levels of 25-OH-VitD in CRSwNP, CRSsNP, and control groups were 12.52, 15.54, and 22.04 ng/ml, respectively. There was a significant difference between the case and control groups in terms of 25-OH-VitD level (P=0.0001). However, no significant difference was observed between the CRSwNP and CRSsNP groups in this regard (P=0.464). The women had a VitD deficiency odds ratio (OR) of 2.47, compared with men (OR=2.47, 95 CI=1.04-5.86). The OR of VitD deficiency with aging was obtained as 0.957 (95 CI=0.925-0.989). In this regard, older patients had a lower probability of VitD deficiency, compared to younger patients. Conclusion: As the findings indicated, serum 25-OH-VitD was significantly lower in CRS patients, compared with that in the non-CRS subjects.

Item Type: Article
Subjects: WV Otolaryngology
Divisions: Journals > Iranian J Otorhinolaryngology
Depositing User: ijo ijo
Date Deposited: 14 Apr 2019 04:44
Last Modified: 14 Apr 2019 04:44
URI: http://eprints.mums.ac.ir/id/eprint/11344

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