The correlation between blood biomarkers and blood lead levels in preeclampsia

Bayat, Fatemeh and Amir Aliakbari, Sedigheh and Dabiri, Atousa and Nasiri, Malihe and Osat Mellati, Ali (2016) The correlation between blood biomarkers and blood lead levels in preeclampsia. The Iranian Journal of Obstetrics, Gynecology and Infertility, 19 (34). pp. 10-17.

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Introduction: Considering the importance of preeclampsia and its effect on hematologic indices, and also the studies showing the effect of lead as a toxic metal on these indices, the present study was performed with aim to investigate the correlation of serum lead with hematologic indices in women with preeclampsia with no occupational exposure to lead. Methods: This correlation study was performed on 80 pregnant women with preeclampsia hospitalized in Zanjan Ayatolah Mousavi hospital in 2015. At entry to the study, 3.5 ml of venous blood samples were taken from participants to assess serum lead level and hematologic indices. Demographic and obstetric characteristics of participates were also recorded. Serum lead level was measured using potentiometric method with Ion3 device, and hematologic indices were analyzed with Symex device. Data were analyzed by SPSS software (version 22) and Chi-square and Pearson correlation test. PResults: Mean serum lead level among 80 participants was 8.04±3.4µg/dl. Blood lead level showed a positive correlation with Platelet Distribution Weight (PDW: r=-0.300, P=0.17), and a negative and significant one with Platelet Large Cell Range (PLCR: r=-0.260, P=0.047). Blood lead level also showed positive significant relationship with BUN (BUN: r=0.377, P=0.001) and blood creatinine (Cr: r=0.288, P=0.012), but showed no relationship with other blood indices. Conclusion: Blood lead affects on blood biomarkers, so it is recommended that strategies be planned and implemented for reducing exposure to environmental lead especially in pregnant women.

Item Type: Article
Subjects: WP Gynecology
WQ Obstetrics
Divisions: Journals > Iranian J Obstetrics, Gynecology and Infertility
Depositing User: ijogi ijogi
Date Deposited: 19 Sep 2017 13:47
Last Modified: 19 Sep 2017 13:47

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