Interactive anticancer effect of nanomicellar curcumin and galbanic acid combination therapy with some common chemotherapeutics in colon carcinoma cells

Jafari, Arash and Teymouri, Manouchehr and Ebrahimi Nik, Maryam and Abbasi, Azam and Iranshahi, Mehrdad and Hanafi-Bojd, Mohammad Yahya and Jafari, Mahmoud Reza (2019) Interactive anticancer effect of nanomicellar curcumin and galbanic acid combination therapy with some common chemotherapeutics in colon carcinoma cells. Avicenna Journal of Phytomedicine, 9 (3). pp. 237-247.

[img] Text
AJP_Volume 9_Issue 3_Pages 237-247.pdf

Download (1MB)
Official URL: http://ajp.mums.ac.ir/article_12265.html

Abstract

Objective: In the current investigation, we aimed to study the combined cytotoxicity of curcumin, as a nanomicellar formulation, and galbanic acid (Gal), dissolved in DMSO against the murine C26 and human Caco-2 colon carcinoma cells. Further, curcumin potential for cisplatin and doxorubicin (Dox) co-therapy was studied. Materials and Methods: The combined cytotoxic effect of these phytochemicals at varying dose ratios were examined using the MTT colorimetric assay. Moreover, the time-dependent toxicity of curcumin, cisplatin, Dox, and pegylated liposomal Dox (Doxil) was determined. The interactive anti-proliferative behavior of these compounds was examined using the CompuSyn software. Results: Nanomicellar curcumin showed considerable cytotoxicity in C26 cells 24 hr post-treatment. Co-treatment of cells with curcumin nanomicelles: Gal had a synergistic effect in C26 (at 10:1 molar ratio), and Caco-2 (at 1:5 molar ratio) cell lines in cell cultures. Nanomicellar curcumin showed strong and mild synergistic inhibitory effects in C26 cells when co-administered with Doxil and cisplatin, respectively. Conclusion: Curcumin nanomicelles and Gal had a synergistic effect in C26 and Caco-2 cell lines. It is speculated that nanomicellar curcumin shows synergistic cancer cell killing if administered 24-hr post-injection of Doxil and cisplatin.

Item Type: Article
Subjects: QT physiology
QU Biochemistry
QV pharmacology
QY Clinical Pathology
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 01 Jul 2019 05:13
Last Modified: 01 Jul 2019 05:13
URI: http://eprints.mums.ac.ir/id/eprint/11713

Actions (login required)

View Item View Item