Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis

Qadiri, Afsaneh and Mirzaei Bavil, Fariba and Hamidian, Gholamreza and Zavvari Oskuye, Zohreh and Ahmadi, Mahdi and Oghbaei, Hajar and Mehri, Keivan and Vatankhah, Amir Mansour and Keyhanmanesh, Rana (2019) Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis. Avicenna Journal of Phytomedicine, 9 (4). pp. 374-385.

[img] Text
AJP_Volume 9_Issue 4_Pages 374-385.pdf

Download (336kB)
Official URL: http://ajp.mums.ac.ir/article_12741.html

Abstract

Objective: The glucose-reducing effects of troxerutin was previously proven. This study was conducted to evaluate troxerutin effect on testicular structure and spermatozoid parameters in type-1 diabetic adult male rats. Materials and Methods: Fifty male Wistar rats were randomly classified into 5 groups as follows: control (C), troxerutin (T), diabetic (DM), troxerutin-treated DM (DT) and insulin-treated DM (DI). Testicular structure, apoptosis, lipid peroxidation and antioxidant activity, and spermatozoid parameters were assessed 4 weeks after initiation of the interventions. Results: The results revealed that diabetes caused testicular stereological changes and significantly increased blood glucose level, testicular MDA content and apoptosis but decreased insulin level, testicular GPX activity, and sperm parameters compared to controls (p Conclusion: Taken together, troxerutin, comparable to insulin, effectively improved DM-induced testicular dysfunction and sperm parameters in diabetic rats and these effects might be mediated through troxerutin�s anti-apoptotic effects.

Item Type: Article
Subjects: WD Nutrition Disease and metabolic diseases
QT physiology
QU Biochemistry
QV pharmacology
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 01 Jul 2019 06:02
Last Modified: 01 Jul 2019 06:02
URI: http://eprints.mums.ac.ir/id/eprint/11732

Actions (login required)

View Item View Item