Effects of saffron on homocysteine, and antioxidant and inflammatory biomarkers levels in patients with type 2 diabetes mellitus: a randomized double-blind clinical trial

Shahbazian, Hajieh and Moravej Aleali, Armaghan and Amani, Reza and Namjooyan, Foroogh and Cheraghian, Bahman and Latifi, Seyed Mhmoud and Bahrainian, Sara and Ghadiri, Ataallah (2019) Effects of saffron on homocysteine, and antioxidant and inflammatory biomarkers levels in patients with type 2 diabetes mellitus: a randomized double-blind clinical trial. Avicenna Journal of Phytomedicine, 9 (5). pp. 436-445.

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Abstract

Objective: Type 2 diabetes mellitus (T2DM) is one of the most common health problems worldwide. Studies have shown that saffron and its derivatives may have therapeutic potentials in T2DM through reducing plasma glucose. The present study aimed to evaluate the effects of saffron extract on serum anti-inflammatory and antioxidant variables in T2DM patients. Materials and Methods: This was a double-blind randomized clinical trial conducted on 64 T2DM patients. Participants received either 15 mg of saffron or placebo capsules (two pills per day) for 3 months Anthropometric indices, homocysteine, serum anti-inflammatory and antioxidant variables and dietary intake were assessed pre- and post-intervention. Results: After 3 months of treatment, interleukin-6 (IL-6), and tumor necrosis factor (TNF-α) increased significantly in both group (p<0.05). No significant differences were observed for total antioxidant capacity (TAC), malondialdehyde (MDA),highsensitivity C-reactive protein (hs-CRP) and interleukin 10(IL-10) after the treatment period (p>0.05). Homocysteine decteased significantly in control group (p<0.05). Conclusion: Our results showed no improvement in homocystein levels, antioxidant status and inflammatory biomarkers in T2DM patients after treatment with saffron.

Item Type: Article
Uncontrolled Keywords: Inflammatory,Antioxidant,Saffron,Type 2 diabetes mellitus,Biomarkers
Subjects: WD Nutrition Disease and metabolic diseases
QT physiology
QU Biochemistry
QY Clinical Pathology
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 25 Sep 2019 08:39
Last Modified: 25 Sep 2019 08:39
URI: http://eprints.mums.ac.ir/id/eprint/12019

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