A Propensity Score Analysis of Renal Dysfunction in Patients after On-Pump and Off-Pump Coronary Artery Bypass Surgery

Vishnu, Rajkamal and Rai, Guruprasad and Bishnoi, Arvind and Sevagur, Ganesh and Balakrishnan, Pranav and gaude, yogesh and Patil, Navin and Budania, Lokvendra (2019) A Propensity Score Analysis of Renal Dysfunction in Patients after On-Pump and Off-Pump Coronary Artery Bypass Surgery. Journal of Cardio-Thoracic Medicine, 7 (3). pp. 474-483.

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INTRODUCTION- Cardiovascular disease has emerged as a major health burden worldwide with coronary artery disease CAD causing highest mortality and morbidity. Coronary revascularization is the preferred treatment for patients with multivessel CAD. Based on the application of cardiopulmonary bypass CPB, Coronary revascularization can be on-pump OPCAB or off-pump CABG.The CPB is known to have multifactorial effects on all end-organ functions due to nonpulsatile flow and inflammation response. Renal function alteration is one of the multiple deleterious effects. There have been reports on superior renal function using off-pump CABG . The present study aimed to investigate and compare the prevalence of renal dysfunction in the two techniques OPCAB versus CABG.METHODS- This was a single-center retrospective study conducted with the data from 199 patients categorized into two groups of off-pump n=106 and on-pump n=93. Renal parameters were monitored on the days 0, 1, 3, 5 after the operation using Glomerular Filtration Rate GFR. Creatinine clearance CrCl of patients with diabetes, hypertension, both diabetes and hypertension, and normal patients was also correlated.RESULTS- Two groups of on-pump and off-pump were combined and classified according to Propensity Score. Renal functions were compared between the two groups no significant difference in renal function between the off-pump and on-pump groups.CONCLUSION-In the present study, there were no significant differences between the two techniques in renal outcomes. Both groups shared an almost similar change of trends in renal functions.

Item Type: Article
Uncontrolled Keywords: Acute renal failure,Coronary Artery Disease,Cardiopulmonary Bypass,glomerular filtration rate,Creatinine clearance
Subjects: WG Cardiovascular System
Divisions: Journals > J Cardio-Thoracic Medicine
Depositing User: jctm jctm
Date Deposited: 29 Sep 2019 09:02
Last Modified: 02 Oct 2019 05:37
URI: http://eprints.mums.ac.ir/id/eprint/12100

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