Bone Mineral Density and Cystic Fibrosis: A Review

Hassanzad, Maryam and Farnia, Poopak and Samadani, Ali Akbar and Sayedi, Seyed Javad and Velayati, Ali Akbar (2019) Bone Mineral Density and Cystic Fibrosis: A Review. International Journal of Pediatrics, 7 (7). pp. 9701-9710.

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Abstract

Cystic fibrosis (CF) is a common progressive genetic disorder among children which involves lungs, kidneys, intestine and liver. Apart from the significance of genetic factors, various environmental factors particularly bone mineral density are directly associated with CF. Remarkably, bone disease is appeared as a routine and common trait in long term CF survivors which implies that environmental parameters including calcium and vitamin D intake as well as drug inducement are the most important risk factors causing low bone mineral density. Conspicuously, absolute and notable treatment of cystic fibrosis associated to bone disorder must involve investigating the risk factors including the reduced intake of certain vitamins and minerals due to pancreatic inadequacy, modified hormone production, severe and chronic lung infection with increased ranges of bone function cytokines for a weak bone health situation. In this review, focus is on these considerable factors alongside the genetic factors in cystic fibrosis. Â

Item Type: Article
Uncontrolled Keywords: Cystic fibrosis,Low Bone Mineral Density,Genetic Factors,Vitamin D
Subjects: WA Public Health
WS Pediatrics
QY Clinical Pathology
Divisions: Journals > International J Pediatrics
Depositing User: IJP IJP
Date Deposited: 11 Oct 2019 15:50
Last Modified: 11 Oct 2019 15:50
URI: http://eprints.mums.ac.ir/id/eprint/12205

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