Role of the cholinergic muscarinic receptors of the CA1 area in the memory impairment induced by iron oxide nanoparticle in adult male rats

Karimi, Azam and Khajehpour, Lotfollah and Kesmati, Mahnaz (2019) Role of the cholinergic muscarinic receptors of the CA1 area in the memory impairment induced by iron oxide nanoparticle in adult male rats. Nanomedicine Journal, 6 (4). pp. 301-310.

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Abstract

Objective(s): Nanoparticles of iron oxide (nFe2O3) are widely used in medicine and industry and could interfere with the brain processes associated with memory. The involvement of muscarinic cholinergic receptors in the process of memory formation has been confirmed. The present study aimed to investigate the possible interference of the cholinergic muscarinic receptors of the dorsal hippocampal CA1 area in the memory impairment induced by nFe2O3 in adult male rats.Materials and Methods: In this study, we examined the possible involvement of the cholinergic muscarinic receptors of the dorsal hippocampal CA1 area in the memory impairment induced by nFe2O3. In total, 70 male rats were divided into 10 groups of saline (1 µl/rat)+saline (1 ml/kg; intraperitoneal IP), saline (1 µl/rat)+nFe2O3 (5 and 7.5 mg/kg; IP), pilocarpine (1 and 2 µg/rat)+saline (1 ml/kg), pilocarpine (1 and 2 µg/rat)+nFe2O3 (7.5 mg/kg; IP), scopolamine (1 and 2 µg/rat)+saline (1 ml/kg), and scopolamine (1 µg/rat)+ nFe2O3 (5 mg/kg; IP).Results: Pilocarpine and scopolamine were injected intra-CA1 after training and before the IP administration of nFe2O3. The latency to enter the dark compartment in the step-through apparatus and locomotor activity was performed on the animals in an open field at 24 hours and seven days after training. The results indicated that nFe2O3 (7.5 mg/kg) decreased memory retrieval (P

Item Type: Article
Uncontrolled Keywords: Cholinergic system,Hippocampus,Iron oxide,Memory,Nanoparticle
Subjects: QT physiology
Divisions: Journals > Nanomedicine Journal
Depositing User: nmj nmj
Date Deposited: 22 Dec 2019 10:20
Last Modified: 22 Dec 2019 10:20
URI: http://eprints.mums.ac.ir/id/eprint/12322

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