Tanacetum parthenium enhances pentobarbital-induced sleeping behaviors

Forouzanfar, Fatemeh and Ghazavi, Hamed and Vahedi, Mohammad Mahdi and Tarah, Kimia and Yavari, Zahra and Hosseini, Azar and Aghaee, Azita and Rakhshandeh, Hasan (2019) Tanacetum parthenium enhances pentobarbital-induced sleeping behaviors. Avicenna Journal of Phytomedicine, 10 (1). pp. 70-77.

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Objective: Sleep disorders are among the most common psychiatric and medical conditions. In the present study, the hypnotic effect of Tanacetum parthenium was studied in mice. Material and Methods: The hydro-alcoholic extract (HAE) of T. parthenium and three fractions of it, namely water fraction (WF), ethyl acetate fraction (EAF), and n-hexane fraction (NHF), were intraperitoneally (ip) administrated to mice 30 min before injection of sodium pentobarbital (30 mg/kg, ip). Then, 30 min after administration of HAE, motor coordination (rota-rod test) was evaluated. Besides, LD50 of HAE was determined and the cytotoxicity of HAE was evaluated in PC12 cells using the MTT assay. Results: HAE 50-200 mg/kg increased the sleeping time. EAF was the only fraction which could prolong the sleep duration and decrease sleep latency. The LD50 value was 4.8 g/kg. The extract induced no cytotoxic effects in PC12 cell line. Conclusion: The results suggested that T. parthenium potentiates pentobarbital hypnosis without causing toxic effects. Probably, its effects are mediated by the components present in EAF of this plant.

Item Type: Article
Uncontrolled Keywords: Pentobarbital,PC12,Sleep,Tanacetum parthenium,Herbal Medicine
Subjects: QT physiology
WL Nervous system
QV pharmacology
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 23 Dec 2019 07:31
Last Modified: 23 Dec 2019 07:31
URI: http://eprints.mums.ac.ir/id/eprint/12332

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