A Pilot Study of FDG-PET/CT in Polycythemia Vera Using Global Analysis Techniques

Ayubcha, Cyrus and Hosoya, Hitomi and Mehdizadeh Seraj, Siavash and Zirakchian Zadeh, Mahdi and Werner, Thomas and Alavi, Abass (2020) A Pilot Study of FDG-PET/CT in Polycythemia Vera Using Global Analysis Techniques. Asia Oceania Journal of Nuclear Medicine and Biology, 8 (1). pp. 64-68.

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Abstract

Objective(s): Functional imaging presents a non-invasive process that may capture the hyper-metabolic nature of red bone marrow in myeloproliferative neoplasms, such as polycythemia vera (PV). Methods: This study analyzed the FDG-PET/CT scans (n=12) of six patients diagnosed with PV and six age-sex matched controls using a quantitative global analysis methodology. Results: All PV patients had elevated activities in the bone marrow of each skeletal structure as compared to matched controls with respect to mean standardized uptake value (femoral neck p=0.01, lumbar spine p=0.02, pelvis p=0.002, sternum p=0.04). Notable variations in splenic uptake were observed among the treated and untreated PV patients. Conclusion: Our study exemplifies the potential utility of PET in reflecting hyperactive bone marrow activity related to PV. Future studies may further substantiate and elaborate on the use of PET-derived metabolic data in PV.

Item Type: Article
Uncontrolled Keywords: Polycythemia Vera,FDG-PET/CT,Myeloproliferative Neoplasm,Non-Invasive Procedure,Global Analysis
Subjects: WN Radiology . Diagnostic Imaging
Divisions: Journals > Asia Oceania J Nuclear Medicine & Biology
Depositing User: AOJNMB AOJNMB
Date Deposited: 19 Jan 2020 06:56
Last Modified: 19 Jan 2020 06:56
URI: http://eprints.mums.ac.ir/id/eprint/12798

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