Various parameters in the preparation of chitosan/polyethylene oxide electrospun nanofibers containing Aloe vera extract for medical applications

Nikbakht, Mohammad and Salehi, Majid and Rezaya, Seyed Mahdi and Majidi, Reza Faridi (2020) Various parameters in the preparation of chitosan/polyethylene oxide electrospun nanofibers containing Aloe vera extract for medical applications. Nanomedicine Journal, 7 (1). pp. 21-28.

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Abstract

Objective(s): The present study aimed to fabricate chitosan/polyethylene oxide (CS/PEO) electrospun nanofibers loaded with Aloe vera extract for biomedical applications. The polymer-to-extract ratio and electrospinning parameters (applied voltage and nozzle-to-collector distance) were evaluated in order to optimize the process of nanofiber fabrication. Materials and Methods: The characterizations were performed using scanning electron microscopy (SEM), ImageJ software, attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR), tensile strength test, and UV-Vis spectroscopy. Results: The obtained results indicated that the fabrication of nanofibers from pure Aloe vera extract was unsuccessful, and reducing the extract concentration from 100 to 92 resulted in the formation of the nanofibers. Moreover, further reduction in the extract from 92 to 50 led to the production of fine nanofibers (mean diameters: 204±42 and 398±51 nm, respectively). Therefore, it was concluded that the reduced concentration of the herbal extract increased the diameters of the prepared nanofibers. In addition, the results of the optimization process indicated a direct correlation between the applied voltage and nanofiber diameters, as well as an inverse correlation between the nozzle-to-collector distance and nanofiber diameters. The FTIR spectroscopy also confirmed the presence of CS, PEO, and Aloe vera in the final prepared scaffold. The release measurement revealed a burst effect within the first five hours, followed by a sustain release within 30 hours. Moreover, the biocompatibility assay confirmed the proliferative potential of Aloe vera within seven days.Conclusion: According to the results, a nanofibrous scaffold composed of CS and PEO could be fabricated as the carrier of Aloe vera extract, which is a suitable platform for biomedical applications.

Item Type: Article
Uncontrolled Keywords: Aloe vera,Chitosan,Electrospinning,Nanofibers,Polyethylene oxide
Subjects: QT physiology
Divisions: Journals > Nanomedicine Journal
Depositing User: nmj nmj
Date Deposited: 20 Jan 2020 06:49
Last Modified: 20 Jan 2020 06:49
URI: http://eprints.mums.ac.ir/id/eprint/12806

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