The prevalence of genes encoding ESBL among clinical isolates of Escherichia coli in Iran: A systematic review and meta-analysis

Ghaderi, R.S. and Yaghoubi, A. and Amirfakhrian, R. and Hashemy, S.I. and Ghazvini, K. (2020) The prevalence of genes encoding ESBL among clinical isolates of Escherichia coli in Iran: A systematic review and meta-analysis. Gene Reports, 18.

[img] Text
1-s2.0-S2452014419302043-main.pdf

Download (3MB)
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Resistance to β-lactams in Enterobacteriaceae, associated with plasmid-mediated extended-spectrum β-lactamases (ESBLs), has become a worldwide problem. The aim of this study is to estimate the prevalence of E. coli ESBL-producing gene in Iran. A comprehensive study and determination of the epidemiology of these genes in the community are necessary to control of ESBLs in the country. We searched international and national databases, including: PubMed, Scopus, Irandoc, Magiran, SID from 2008 to 2018, also available Congress of Iranian Medical Microbiology, for articles and abstracts describing the prevalence of genes encoding ESBL among clinical isolates of E. coli in Iran. Finally, sixty-eight studies that met our inclusion criteria were included in this meta-analysis, the outcome was combined using a random-effects model these were constructed for the event rate of genes encoding ESBL among clinical isolates of E. coli. Data were analyzed with the comprehensive Meta-Analysis (Ver2) software and the heterogeneity of studies was assessed using the I2 index. The prevalence rate of blaTEM encoding ESBL in E. coli was 51 summary: 95% CI = 46�57, I2 = 78.66, df (Q) = 30, Q-value = 140.589, P < 0.49 and prevalence of blaSHV was reported 37% summary: 95% CI = 30�45, I2 = 83.35, df (Q) = 22, Q-value = 132.147, P < 0.003. The frequency of blaCTX-M gene among ESBL producing E. coli isolates was 45% summary: 95% CI = 36�55, I2 = 93.65, df (Q) = 27, Q-value = 425.553, P < 0.37. The small number of studies limited power to detect associations and sources of heterogeneity. According to the result of this meta-analysis, the prevalence rate of ESBLs has been significantly increased in different regions of Iran, so this result could be useful to find a strategic policy for reducing the prevalence of ESBLs-producing E. coli. © 2019

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: extended spectrum beta lactamase, bacterium isolate; Escherichia coli; Iran; Medline; nonhuman; polymerase chain reaction; prevalence; priority journal; Review; Scopus; systematic review
Subjects: QW Microbiology and Immunology
Divisions: Faculty of Medicine
Depositing User: sasan raisian
Date Deposited: 01 Feb 2020 09:18
Last Modified: 01 Feb 2020 09:18
URI: http://eprints.mums.ac.ir/id/eprint/12817

Actions (login required)

View Item View Item