TiCl2·2H2O catalyzed one-pot synthesis of highly functionalized tetrahydropiperidines and evaluation of their antimicrobial activities

Abbasi, M. and Seyedi, S. M. and Sadeghian, H. and Akhbari, M. and Enayaty, M. and Shiri, A. (2016) TiCl2·2H2O catalyzed one-pot synthesis of highly functionalized tetrahydropiperidines and evaluation of their antimicrobial activities. Heterocyclic Communications, 22 (3). pp. 117-121.

[img] Text
[Heterocyclic Communications] TiCl22H2O catalyzed one-pot synthesis of highly functionalized tetrahydropiperidines and evaluation of their antimicrobial activities.pdf

Download (218kB)

Abstract

One-pot condensation reaction of ethyl acetoacetate, various substituted benzaldehydes and anilines in the presence of TiCl2·2H2O yields highly functionalized tetrahydropiperidines. Atom economy, efficiency, and short reaction times are the advantages of the method, which is carried out under mild conditions using easily accessible and inexpensive chemicals. The antimicrobial activity of the synthesized products was evaluated against three Gram-positive and three Gram-negative bacteria, a yeast and a fungus strain using disc diffusion and minimum inhibitory concentration methods. © 2016 by De Gruyter.

Item Type: Article
Additional Information: Cited By :4 Export Date: 16 February 2020 CODEN: HCOME Correspondence Address: Seyedi, S.M.; Department of Chemistry, Faculty of Science, Ferdowsi University of MashhadIran; email: smseyedi@um.ac.ir
Uncontrolled Keywords: Antibacterial activity multicomponent reaction tetrahydropiperidine TiCl2·2H2O
Subjects: QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 03 Mar 2020 10:51
Last Modified: 03 Mar 2020 10:51
URI: http://eprints.mums.ac.ir/id/eprint/12889

Actions (login required)

View Item View Item