Detection of prostate cancer by an FDG-PET cancer screening program: results from a Japanese nationwide survey

Minamimoto, Ryogo and Senda, Michio and Jinnouchi, Seishi and Terauchi, Takashi and Inoue, Tomio (2014) Detection of prostate cancer by an FDG-PET cancer screening program: results from a Japanese nationwide survey. Asia Oceania Journal of Nuclear Medicine and Biology, 2 (1). pp. 19-23.

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Abstract

Objective(s): The aim of this study was to analyze detection rates and effectiveness of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) cancer screening program for prostate cancer in Japan, which is defined as a cancer-screening program for subjects without known cancer. It contains FDG-PET aimed at detection of cancer at an early stage with or without additional screening tests such as prostate-specific antigen (PSA) and magnetic resonance imaging (MRI). Methods: A total of 92,255 asymptomatic men underwent the FDG-PET cancer screening program. Of these, 504 cases with findings of possible prostate cancer in any screening method were analyzed. Results: Of the 504 cases, 165 were verified as having prostate cancer. Of these, only 61 cases were detected by FDG-PET, which result in 37.0 relative sensitivity and 32.8 positive predictive value (PPV). The sensitivity of PET/computed tomography (CT) scanner was higher than that of dedicated PET (44.0 vs. 20.4). However, the sensitivity of FDGPET was lower than that of PSA and pelvic MRI. FDG-PET did not contribute to improving the sensitivity and PPV when performed as combined screening. Conclusion: PSA should be included in FDG-PET cancer screening programs to screen for prostate cancer.

Item Type: Article
Subjects: WN Radiology . Diagnostic Imaging
Divisions: Journals > Asia Oceania J Nuclear Medicine & Biology
Depositing User: AOJNMB AOJNMB
Date Deposited: 19 Sep 2017 14:25
Last Modified: 19 Sep 2017 14:25
URI: http://eprints.mums.ac.ir/id/eprint/1289

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