Protective role of R381Q (rs11209026) polymorphism in IL-23R gene in immune-mediated diseases: A comprehensive review

Abdollahi, E. and Tavasolian, F. and Momtazi-Borojeni, A. A. and Samadi, M. and Rafatpanah, H. (2016) Protective role of R381Q (rs11209026) polymorphism in IL-23R gene in immune-mediated diseases: A comprehensive review. Journal of Immunotoxicology, 13 (3). pp. 286-300.

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Protective role of R381Q rs11209026 polymorphism in IL 23R gene in immune mediated diseases A comprehensive review.pdf

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Abstract: Interleukin-23 (IL-23) is a regulator of cellular immune responses involved in controlling infection and autoimmune diseases. Strong evidence has shown that IL-23 plays a role in the maintenance of immune responses by influencing the proliferation and survival of IL-17-producing T-helper (TH)-17 cells. The critical role of the IL-23/TH17 axis in immune-mediated diseases has emerged from different studies. It has also been seen that polymorphisms in the IL-23 receptor (IL-23R) gene might influence IL-23 responses. Interestingly, a functional single nucleotide polymorphism (SNP) in the IL-23 receptor gene (IL-23R; rs11209026, 1142 G wild-type A reduced function, Arg381Gln, R381Q) seems to confer a measure of protection against development of inflammatory bowel disease (IBD; Crohn’s disease, ulcerative colitis), ankylosing spondylitis, rheumatoid arthritis, psoriasis, thyroiditis, recurrent spontaneous abortion and asthma, suggesting that a perturbation in the IL-23 signaling pathway is likely to be relevant to the pathophysiology of these diseases. The aim of this review was to provide an evaluation of what is currently known about the protective role of R381Q variant in IL-23R gene in immune-based diseases. © 2016 Informa UK Limited trading as Taylor & Francis Group.

Item Type: Article
Additional Information: Cited By :17 Export Date: 16 February 2020 Correspondence Address: Rafatpanah, H.; Inflammation and Inflammatory Diseases Research Center, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: IL-23R gene immune-mediated diseases R381Q (rs11209026) polymorphism interleukin 17 interleukin 23 receptor IL23R protein, human interleukin 23 interleukin receptor ankylosing spondylitis asthma autoimmune disease cell proliferation cell survival cellular immunity Crohn disease DNA polymorphism gene interaction genetic susceptibility genetic variation inflammatory bowel disease pathophysiology priority journal psoriasis Review rheumatoid arthritis signal transduction single nucleotide polymorphism spontaneous abortion Th17 cell thyroiditis ulcerative colitis animal genetic predisposition genetics human immunology inflammation metabolism Animals Autoimmune Diseases Genetic Predisposition to Disease Humans Inflammatory Bowel Diseases Interleukin-23 Polymorphism, Single Nucleotide Receptors, Interleukin Th17 Cells
Subjects: QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 03 Mar 2020 10:54
Last Modified: 03 Mar 2020 10:54

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