A Review on Potential Mechanisms of Terminalia chebula in Alzheimer's Disease

Afshari, A. R. and Sadeghnia, H. R. and Mollazadeh, H. (2016) A Review on Potential Mechanisms of Terminalia chebula in Alzheimer's Disease. Advances in Pharmacological Sciences, 2016.

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The current management of Alzheimer's disease (AD) focuses on acetylcholinesterase inhibitors (AChEIs) and NMDA receptor antagonists, although outcomes are not completely favorable. Hence, novel agents found in herbal plants are gaining attention as possible therapeutic alternatives. The Terminalia chebula (Family: Combretaceae) is a medicinal plant with a wide spectrum of medicinal properties and is reported to contain various biochemicals such as hydrolysable tannins, phenolic compounds, and flavonoids, so it may prove to be a good therapeutic alternative. In this research, we reviewed published scientific literature found in various databases: PubMed, Science Direct, Scopus, Web of Science, Scirus, and Google Scholar, with the keywords: T. chebula, AD, neuroprotection, medicinal plant, antioxidant, ellagitannin, gallotannin, gallic acid, chebulagic acid, and chebulinic acid. This review shows that T. chebula extracts and its constituents have AChEI and antioxidant and anti-inflammatory effects, all of which are currently relevant to the treatment of Alzheimer's disease. Copyright © 2016 Amir R. Afshari et al.

Item Type: Article
Additional Information: Cited By :29 Export Date: 16 February 2020 Correspondence Address: Mollazadeh, H.; Neurocognitive Research Center, School of Medicine, Mashhad University of Medical SciencesIran; email: mollazadehh901@mums.ac.ir
Uncontrolled Keywords: acetylcholinesterase antiinflammatory agent antioxidant chebulagic acid chebulinic acid cholinesterase inhibitor ellagitannin gallic acid phenol derivative tannin tannin derivative Terminalia chebula extract unclassified drug Alzheimer disease antiinflammatory activity antioxidant activity chemical composition data base drug mechanism human neuroprotection nonhuman phytochemistry priority journal Review structure activity relation Terminalia chebula
Subjects: WT Geriatrics . Chronic Diseases
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 03 Mar 2020 10:23
Last Modified: 03 Mar 2020 10:23
URI: http://eprints.mums.ac.ir/id/eprint/12894

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