Prediction of optimum combination of eudragit RS/eudragit RL/ethyl cellulose polymeric free films based on experimental design for using as a coating system for sustained release theophylline pellets

Akhgari, A. and Tavakol, A. (2016) Prediction of optimum combination of eudragit RS/eudragit RL/ethyl cellulose polymeric free films based on experimental design for using as a coating system for sustained release theophylline pellets. Advanced Pharmaceutical Bulletin, 6 (2). pp. 219-225.

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Abstract

Purpose: The physicochemical properties of free films made from different mixtures of sustained release polymers were investigated, and an optimum formulation coating on drug containing pellets, based on the study of free film was evaluated. Methods: In order to determine the effect of different variables on the permeability and swelling of films and procedure optimization, the experimental design was fulfilled based on the statistical method of a 33 full factorial design, and according to this method 27 formulations were prepared. The films were prepared using casting-solvent evaporation method. Water vapor permeability, the swelling and permeability of free films in both acidic and buffer media, were carried out. Then, the pellets containing theophylline were coated with the optimum formulation. Results: The results of this study demonstrated that an increase in the free film thickness and Eurdragit RS ratio in films lowered the water vapor transmission (WVT), the swelling and the permeability of all formulations, while an increase in the quantity of ethylcellulose, up to a specific ratio (approximately 40), decreased the permeability and swelling. The most optimum free film formulation was made up of 60 Eudragit RS and 40 ethylcellulose. Conclusion: Pellets coated with a 10 coating level of ethylcellulose and Eudragit RS (4:6) showed suitable release properties and could serve as a favorable sustained release system for theophylline. © 2016 The Authors.

Item Type: Article
Additional Information: Cited By :8 Export Date: 16 February 2020 Correspondence Address: Akhgari, A.; Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical SciencesIran; email: akhgaria@mums.ac.ir
Uncontrolled Keywords: Ethylcellulose Eudragit Permeability Sustained release Swelling Theophylline buffer ethyl cellulose eudragit rs polymer acidity Article controlled study drug coating drug delivery system drug pellet evaporation experimental design factorial design pharmacological parameters physical chemistry physical parameters prediction process optimization solvent effect statistical analysis sustained release formulation thickness water vapor permeability water vapor transmission
Subjects: WA Public Health
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 03 Mar 2020 09:54
Last Modified: 03 Mar 2020 09:54
URI: http://eprints.mums.ac.ir/id/eprint/12908

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