Recent Advances in Immunoliposome-Based Cancer Therapy

Alavizadeh, S. H. and Soltani, F. and Ramezani, M. (2016) Recent Advances in Immunoliposome-Based Cancer Therapy. Current Pharmacology Reports, 2 (3). pp. 129-141.

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Abstract

Advances in protein engineering have revolutionized nanomedicine by introducing novel nanocarriers for delivery of cancer therapeutics. Designing assemblies that simultaneously incorporate therapeutics and target the site of disease has been the focus of recent studies. Such devices have been developed to behave dynamically in response to certain cues to trigger drug release. Immunoliposomes have been regarded as an attractive drug targeting vehicle for cancer treatment. In the present review, we focus on recent advances in the design of immunoliposomes incorporating a variety of chemotherapeutics that simultaneously exhibit specific target-cell interactions and stimuli-sensitivity. We provided an overview of different stimuli-responsive immunoliposomes that are capable of controlling release of drug in response to either exogenous (temperature, light, and magnetic field) or endogenous (changes in pH and enzyme concentration) stimuli. We have discussed examples of stimuli-sensitive immunoliposomes with respect to each stimuli and their therapeutic potential for cancer treatment. © 2016, Springer International Publishing AG.

Item Type: Article
Additional Information: Cited By :3 Export Date: 16 February 2020 Correspondence Address: Ramezani, M.; Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical SciencesIran; email: ramezanim@mums.ac.ir
Uncontrolled Keywords: Antibody Enzymes Immunoliposomes Stimuli-responsive carriers Temperature avidin beta glucuronidase calcein carboxyfluorescein chemokine receptor CXCR4 cisplatin combretastatin concanavalin A cytarabine daunorubicin doxorubicin epirubicin ferric oxide gelatinase A gemcitabine glucuronide green fluorescent protein immunoliposome macrogol derivative neutrophil gelatinase associated lipocalin phosphatidylethanolamine plasmid DNA technetium 99m uridine vasculotropin antibody directed enzyme prodrug therapy antineoplastic activity apoptosis cancer therapy cell interaction cytotoxicity endocytosis human molecularly targeted therapy multidrug resistance nonhuman pH priority journal protein engineering Review stimulus response tumor microenvironment ultraviolet irradiation
Subjects: QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 03 Mar 2020 10:11
Last Modified: 03 Mar 2020 10:11
URI: http://eprints.mums.ac.ir/id/eprint/12911

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