Comparative study evaluating efficacy of sufentanil versus midazolam in preventing myoclonic movements following etomidate

Alipour, M. and Tabari, M. and Azad, A. M. (2016) Comparative study evaluating efficacy of sufentanil versus midazolam in preventing myoclonic movements following etomidate. Journal of Anaesthesiology Clinical Pharmacology, 32 (1). pp. 29-32.

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Abstract

Background and Aims: Myoclonus is a major side-effect following etomidate injection requiring use of medical intervention. Material and Methods: In this double-blinded clinical trial, 50 consecutive patients, randomly received sufentanil 0.2 μg/kg or midazolam 0.015 mg/kg, 90 s before induction of anesthesia with etomidate (0.3 mg/kg). Then, the patients were monitored for any myoclonic movements during anesthesia. Results: The incidence of myoclonus was 28 in the sufentanil group and 84 in the midazolam group. The frequency and intensity of myoclonus were significantly higher in the midazolam group, compared to the sufentanil group (P < 0.001). Myoclonus duration in the sufentanil and midazolam groups were 5.8 ± 13.2 and 69 ± 47.8 s, respectively (P < 0.0010). Conclusion: The frequency, intensity and duration of myoclonus in the midazolam group, were significantly more prevalent than the sufentanil group. © 2016 Journal of Anaesthesiology Clinical Pharmacology | Published by Wolters Kluwer - Medknow.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 CODEN: JAPHF Correspondence Address: Alipour, M.; Department of Anesthesiology, Ghaem Hospital, Mashhad University of Medical SciencesIran; email: Alipourm@mums.ac.ir
Uncontrolled Keywords: Etomidate midazolam myoclonus sufentanil adult Article clinical article comparative study controlled study disease severity double blind procedure drug efficacy female human male middle aged randomized controlled trial treatment outcome
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 03 Mar 2020 07:08
Last Modified: 03 Mar 2020 07:08
URI: http://eprints.mums.ac.ir/id/eprint/12913

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