Black Cumin (Nigella sativa) and Its Active Constituent, Thymoquinone: An Overview on the Analgesic and Anti-inflammatory Effects

Amin, B. and Hosseinzadeh, H. (2016) Black Cumin (Nigella sativa) and Its Active Constituent, Thymoquinone: An Overview on the Analgesic and Anti-inflammatory Effects. Planta Medica, 82 (1-2). pp. 8-16.

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For many centuries, seeds of Nigella sativa (black cumin), a dicotyledon of the Ranunculaceae family, have been used as a seasoning spice and food additive in the Middle East and Mediterranean areas. Traditionally, the plant is used for asthma, hypertension, diabetes, inflammation, cough, bronchitis, headache, eczema, fever, dizziness, and gastrointestinal disturbances. The literature regarding the biological activities of seeds of this plant is extensive, citing bronchodilative, anti-inflammatory, antinociceptive, antibacterial, hypotensive, hypolipidemic, cytotoxic, antidiabetic, and hepatoprotective effects. The active ingredients of N. sativa are mainly concentrated in the fixed or essential oil of seeds, which are responsible for most health benefits. This review will provide all updated reported activities of this plant with an emphasis on the antinociceptive and anti-inflammatory effects. Results of various studies have demonstrated that the oil, extracts, and their active ingredients, in particular, thymoquinone, possess antinociceptive and anti-inflammatory effects, supporting the common folk perception of N. Sativa as a potent analgesic and anti-inflammatory agent. Many protective properties are attributed to reproducible radical scavenging activity as well as an interaction with numerous molecular targets involved in inflammation, including proinflammatory enzymes and cytokines. However, there is a need for further investigations to find out the precise mechanisms responsible for the antinociceptive and anti-inflammatory effects of this plant and its active constituents. © Georg Thieme Verlag KG Stuttgart · New York.

Item Type: Article
Additional Information: Cited By :66 Export Date: 16 February 2020 CODEN: PLMEA Correspondence Address: Hosseinzadeh, H.; Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Department of Pharmacodynamics and ToxicologyIran; email:
Uncontrolled Keywords: analgesia activity anti-inflammatory effect Nigella sativa Ranunculaceae thymoquinone alanine aminotransferase alkaloid aspartate aminotransferase carbohydrate gamma glutamyltransferase glucose mineral oil plant medicinal product triacylglycerol vitamin analgesic agent benzoquinone derivative nonsteroid antiinflammatory agent plant extract alanine aminotransferase blood level analgesic activity antiinflammatory activity antioxidant activity aspartate aminotransferase blood level asthma backache black cumin bronchitis chemical composition chronic toxicity common cold coughing diabetes mellitus dizziness drug mechanism drug safety eczema fever gamma glutamyl transferase blood level gastrointestinal symptom glucose blood level headache human hypertension in vitro study in vivo study inflammation leukocyte medicinal plant nonhuman nose obstruction phase 1 clinical trial (topic) Review side effect skin allergy skin disease skin irritation triacylglycerol blood level wound animal chemistry Analgesics Animals Anti-Inflammatory Agents, Non-Steroidal Benzoquinones Humans Plant Extracts
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 03 Mar 2020 07:16
Last Modified: 03 Mar 2020 07:16

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