Treatment outcomes and prognostic factors in adult astrocytoma: In North East of Iran

Anvari, K. and Toussi, M. S. and Shahidsales, S. and Motlagh, F. and Ehsaee, M. R. and Afshari, F. (2016) Treatment outcomes and prognostic factors in adult astrocytoma: In North East of Iran. International Journal of Cancer Management, 9 (4).

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Abstract

Background: Astrocytomas are the most common primary adult brain tumors. Objectives: In this study, we investigated the impact of some potential prognostic factors on survival in patients with low and high grade astrocytomas. Patients and Methods: This retrospective cohort study was performed on patients with brain astrocytoma who were referred to oncology departments, Omid and Ghaem hospitals, Mashhad University of Medical Sciences (2000 - 2011). Results: 415 patients with a median age of 43 and a male to female ratio of 252:163 (1.54) were recorded. Grade I to IV astrocytoma were found in 40 (9.6), 88 (21.2), 71 (17.1) and 216 (52) patients. With a median follow up time of 37 months for low grade and 13 months for high grade astrocytoma, the 5-year survival in grades I to IV was 92.1, 69.1, 49.2 and 9.6 respectively. In low grade astrocytomas, patients with grade I tumors, being ambulatory (5-year survival: 88 vs. 60.3, P < 0.001) and performing optimal surgery (5-year survival 86 vs. 59.3, P < 0.001) were associated with more favorable survival. In high grade astrocytomas, patients with grade III tumors, age < 50 (5-year survival 29.6 vs. 14.6, P < 0.001), being ambulatory (5-year survival 39.4 vs. 10.5, P < 0.001), performing optimal surgery (5-year survival 46.1 vs. 4.3, P < 0.001) and receiving chemotherapy (5-year survival 23.7 vs. 18.7, P = 0.02) were associated with significantly higher overall survival. Conclusions: Performing optimal surgery and good performance status were associated with more favorable survival in both low and high grade astrocytomas. In high grade a strocytomas, patients younger than 43 and those who received chemotherapy had better overall survival. © 2016, Iranian Journal of Cancer Prevention.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Toussi, M.S.; Cancer Research Center, Faculty of Medicine, Mashhad University of Medical SciencesIran; email: silanianm@mums.ac.ir
Uncontrolled Keywords: Astrocytoma Overall survival Prognostic factor carmustine vincristine adolescent adult aged Article cancer chemotherapy cancer grading cancer prognosis cancer surgery cancer survival cohort analysis controlled study female human Iran major clinical study male oncology ward retrospective study sex ratio survival time treatment outcome university hospital
Subjects: WT Geriatrics . Chronic Diseases
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 03 Mar 2020 07:37
Last Modified: 03 Mar 2020 07:37
URI: http://eprints.mums.ac.ir/id/eprint/12919

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