Microembolic signals in patients with systemic lupus erythematosus

Azarpazhooh, M. R. and Mokhber, N. and Orouji, E. and Chambers, B. R. and Hatef, M. R. and Rezaieyazdi, Z. and Sedighi, S. and Foroghipoor, M. and Velayati, A. and Gharavi, M. M. (2010) Microembolic signals in patients with systemic lupus erythematosus. Canadian Journal of Neurological Sciences, 37 (3). pp. 371-375.

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Abstract

Introduction: Central nervous system (CNS) involvement is a common and less understood aspect of systemic lupus erythematosus (SLE). Microembolic signals (MES) have been reported in SLE. We conducted a prospective study to evaluate the frequency of MES among patients with CNS involvement and those without. The main aim of the study is to clarify the pathophysiology of the CNS involvement in SLE. Methods and Materials: Sixty eight patients with a diagnosis of SLE (60 females, 8 males) participated in the study. Both middle cerebral arteries were monitored using transcranial Doppler for 60 min to detect MES. All cases underwent neurology and psychiatry assessments. Results: MES were detected in 7/68 patients (10.3) with the mean number of 3.5 per hour. MES were significantly higher in patients with CNS involvement (6/24, 25) than those without (1/44, 2.2) (P=0.006). SLE disease activity index, duration of disease, plaque formation, intima-media thickness, and antiphospholipid antibodies were not associated with MES. MES were more frequent in patients receiving Aspirin and/or Warfarin (p=0.02). Conclusions: MES may be a predictor for CNS involvement in SLE patients at risk for neuropsychiatric syndromes. Cerebral embolism may be implicated in the pathophysiology of neuropsychiatric SLE.

Item Type: Article
Additional Information: Cited By :6 Export Date: 16 February 2020 CODEN: CJNSA Correspondence Address: Azarpazhooh, M. R.; Department of Neurology, Ghaem Medical Center, Mashhad University of Medical Science, Taghi Abad Square, Mashhad, Iran
Uncontrolled Keywords: acetylsalicylic acid phospholipid antibody warfarin adult arterial wall thickness article Bender test brain embolism central nervous system disease activity disease association disease duration Doppler echography female human major clinical study male middle cerebral artery mini mental state examination neurologic examination neuropsychiatry pathophysiology priority journal prospective study psychiatry systemic lupus erythematosus Wechsler Intelligence Scale
Subjects: WR Dermatology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 03 Mar 2020 06:49
Last Modified: 03 Mar 2020 06:49
URI: http://eprints.mums.ac.ir/id/eprint/12931

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