Cytokine profiles in overweight and obese subjects and normal weight individuals matched for age and gender

Azizian, M. and Mahdipour, E. and Mirhafez, S. R. and Shoeibi, S. and Nematy, M. and Esmaily, H. and Ferns, G. A. A. and Ghayour-Mobarhan, M. (2016) Cytokine profiles in overweight and obese subjects and normal weight individuals matched for age and gender. Annals of Clinical Biochemistry, 53 (6). pp. 663-668.

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Abstract

Background: Obesity is associated with a state of systemic inflammation, mediated by adipose tissue-derived cytokines that may also have metabolic effects, including an effect on insulin resistance. The aim of this study was to compare the serum profile of pro- and anti-inflammatory cytokines in obese and non-obese subjects. Methods: A total of 242 subjects who were either overweight or obese (body mass index BMI ≥ 25 kg/m2) and non-obese subjects (body mass index <25 kg/m2), were recruited in Mashhad in northeastern Iran. The concentrations of serum interleukin-1α, -1β, -2, -4, -6, -8 and -10 (IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8 and IL-10), were measured in all subjects, together with serum vascular endothelial growth factor, interferon-γ, epidermal growth factor, monocyte chemoattractant protein-1 and tumour necrosis factor-α. Results: The groups differed significantly with respect to measures of adiposity and fasted lipid profile. Serum pro-inflammatory cytokines interferon-γ and interleukin-1α, and anti-inflammatory cytokines, interleukin-10, and epidermal growth factor were significantly different between obese and non-obese individuals, as was serum high-sensitivity C-reactive protein. Multivariate regression showed that waist circumference was significantly and independently related to serum monocyte chemoattractant protein-1concentrations (P = 0.001). Conclusion: Despite significant differences in several cytokines between the groups, only monocyte chemoattractant protein-1appeared to be independently related to a measure of adiposity in this population sample from Iran. © 2016, © The Author(s) 2016.

Item Type: Article
Additional Information: Cited By :7 Export Date: 16 February 2020 CODEN: ACBOB Correspondence Address: Ghayour-Mobarhan, M.; Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical SciencesIran; email: ghayourm@mums.ac.ir
Uncontrolled Keywords: anthropometric features Inflammatory cytokines lipid profile obese C reactive protein cytokine epidermal growth factor gamma interferon interleukin 10 interleukin 1alpha interleukin 1beta interleukin 2 interleukin 4 interleukin 6 interleukin 8 lipid monocyte chemotactic protein 1 tumor necrosis factor vasculotropin CCL2 protein, human IFNG protein, human interleukin derivative vasculotropin A VEGFA protein, human adult age Article body mass body weight controlled study female gender human major clinical study male obesity priority journal protein blood level waist circumference adipose tissue blood case control study gene expression genetics insulin resistance metabolism middle aged pathology Body Mass Index C-Reactive Protein Case-Control Studies Chemokine CCL2 Humans Interferon-gamma Interleukins Tumor Necrosis Factor-alpha Vascular Endothelial Growth Factor A
Subjects: WD Nutrition Disease and metabolic diseases
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 03 Mar 2020 06:51
Last Modified: 03 Mar 2020 06:51
URI: http://eprints.mums.ac.ir/id/eprint/12932

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