Protective effect of PPAR γ agonists on cerebellar tissues oxidative damage in hypothyroid rats

Baghcheghi, Y. and Beheshti, F. and Salmani, H. and Soukhtanloo, M. and Hosseini, M. (2016) Protective effect of PPAR γ agonists on cerebellar tissues oxidative damage in hypothyroid rats. Neurology Research International, 2016.

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Abstract

The aim of the current study was to investigate the effects of peroxisome proliferator-activated receptor gamma (PPARγ) agonists on cerebellar tissues oxidative damage in hypothyroid rats. The animals included seven groups: group I (control), the animals received drinking water; group II, the animals received 0.05 propylthiouracil (PTU) in drinking water; besides PTU, the animals in groups III, IV, V, VI, and VII, were injected with 20 mg/kg vitamin E (Vit E), 10 or 20 mg/kg pioglitazone, and 2 or 4 mg/kg rosiglitazone, respectively. The animals were deeply anesthetized and the cerebellar tissues were removed for biochemical measurements. PTU administration reduced thiol content, superoxide dismutase (SOD), and catalase (CAT) activities in the cerebellar tissues while increasing malondialdehyde (MDA) and nitric oxide (NO) metabolites. Vit E, pioglitazone, and rosiglitazone increased thiol, SOD, and CAT in the cerebellar tissues while reducing MDA and NO metabolites. The results of present study showed that, similar to Vit E, both rosiglitazone and pioglitazone as PPARγ agonists exerted protective effects against cerebellar tissues oxidative damage in hypothyroid rats. © 2016 Yousef Baghcheghi et al.

Item Type: Article
Additional Information: Cited By :10 Export Date: 16 February 2020 Correspondence Address: Hosseini, M.; Neurocognitive Research Center, Faculty of Medicine, Mashhad University of Medical SciencesIran; email: hosseinim@mums.ac.ir
Uncontrolled Keywords: alpha tocopherol catalase drinking water malonaldehyde nitric oxide pioglitazone propylthiouracil rosiglitazone superoxide dismutase thiol animal experiment animal tissue Article cerebellar tissue controlled study drug effect drug efficacy hypothyroidism lipid peroxidation male metabolite nonhuman oxidative stress rat
Subjects: WK Endocrine System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 03 Mar 2020 07:01
Last Modified: 03 Mar 2020 07:01
URI: http://eprints.mums.ac.ir/id/eprint/12935

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