A comparison study on various low energy sources in interstitial prostate brachytherapy

Bakhshabadi, M. and Ghorbani, M. and Khosroabadi, M. and Knaup, C. and Meigooni, A. S. (2016) A comparison study on various low energy sources in interstitial prostate brachytherapy. Journal of Contemporary Brachytherapy, 8 (1). pp. 74-81.

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Abstract

Purpose: Low energy sources are routinely used in prostate brachytherapy. 125I is one of the most commonly used sources. Low energy 131Cs source was introduced recently as a brachytherapy source. The aim of this study is to compare dose distributions of 125I, 103Pd, and 131Cs sources in interstitial brachytherapy of prostate. Material and methods: ProstaSeed 125I brachytherapy source was simulated using MCNPX Monte Carlo code. Additionally, two hypothetical sources of 103Pd and 131Cs were simulated with the same geometry as the ProstaSeed 125I source, while having their specific emitted gamma spectra. These brachytherapy sources were simulated with distribution of forty-eight seeds in a phantom including prostate. The prostate was considered as a sphere with radius of 1.5 cm. Absolute and relative dose rates were obtained in various distances from the source along the transverse and longitudinal axes inside and outside the tumor. Furthermore, isodose curves were plotted around the sources. Results: Analyzing the initial dose profiles for various sources indicated that with the same time duration and air kerma strength, 131Cs delivers higher dose to tumor. However, relative dose rate inside the tumor is higher and outside the tumor is lower for the 103Pd source. Conclusions: The higher initial absolute dose in cGy/(h.U) of 131Cs brachytherapy source is an advantage of this source over the others. The higher relative dose inside the tumor and lower relative dose outside the tumor for the 103Pd source are advantages of this later brachytherapy source. Based on the total dose the 125I source has advantage over the others due to its longer half-life. © 2016, Termedia Publishing House Ltd. All rights reserved.

Item Type: Article
Additional Information: Cited By :4 Export Date: 16 February 2020 Correspondence Address: Khosroabadi, M.; Faculty of Medicine, North Khorasan University of Medical SciencesIran; email: mohsen.khosroabadi83@gmail.com
Uncontrolled Keywords: 103Pd 125I 131Cs Monte Carlo simulation Prostate brachytherapy Prostate cancer cesium 131 iodine 125 palladium 103 radioisotope Article brachytherapy clinical evaluation comparative study computer program drug half life gamma radiation geometry low energy brachytherapy Monte Carlo method phantom radiation dose distribution
Subjects: WN Radiology . Diagnostic Imaging
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 03 Mar 2020 05:49
Last Modified: 03 Mar 2020 05:49
URI: http://eprints.mums.ac.ir/id/eprint/12940

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