Is type 2 diabetes mellitus in mechanically ventilated adult trauma patients potentially related to the occurrence of ventilator-associated pneumonia?

Darvishi-Khezri, H. and Alipour, A. and Zeydi, A. E. and Firouzian, A. and Mahmudi, G. and Omrani-Nava, M. (2016) Is type 2 diabetes mellitus in mechanically ventilated adult trauma patients potentially related to the occurrence of ventilator-associated pneumonia? Journal of Research in Medical Sciences, 21 (2).

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Abstract

Background: Ventilator-associated pneumonia (VAP) is a type of lung infection that typically affects critically ill patients undergoing mechanical ventilation (MV) in the intensive care unit (ICU). Patients with type 2 diabetes mellitus (T2DM) are considered to be more susceptible to several types of infections including community-acquired pneumonia. However, it is not clear whether T2DM is a risk factor for the development of VAP. The purpose of this study was to determine the risk of VAP for diabetic and nondiabetic mechanically ventilated trauma patients. Materials and Methods: This study is a secondary analysis of a prospective observational study of the history of T2DM in the ICU over a period of 1 year at Imam Khomeini Hospital in Iran. A total of 186 critically ill trauma patients who required at least 48 h of MV were monitored for the occurrence of VAP by their clinical pulmonary infection score (CPIS) until ICU discharge, VAP diagnosis, or death. Results: Forty-one of the 186 patients developed VAP. The median time from hospitalization to VAP was 29.09 days (95 CI: 26.27–31.9). The overall incidence of VAP was 18.82 cases per 1,000 days of intubation (95 CI: 13.86-25.57). Risk of VAP in diabetic patients was greater than nondiabetic patients after adjustments for other potential factors hazard ratio (HR): 10.12 95 confidence interval (CI): 5.1–20.2); P < 0.0001)]. Conclusion: The findings show that T2DM is associated with a significant increase in the occurrence of VAP in mechanically ventilated adult trauma patients. © 2016 Journal of Research in Medical Sciences.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Darvishi-Khezri, H.; Department of Nursing, Sari Branch, Islamic Azad UniversityIran; email: hadidarvishi@iausari.ac.ir
Uncontrolled Keywords: Diabetes mellitus Intensive care unit (ICU) Trauma Ventilator-associated pneumonia (VAP) insulin adult aged Article artificial ventilation controlled study critically ill patient disease association female follow up hazard ratio human injury insulin treatment intensive care unit length of stay major clinical study male morbidity non insulin dependent diabetes mellitus nonhuman ventilator associated pneumonia
Subjects: WT Geriatrics . Chronic Diseases
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 03 Mar 2020 04:45
Last Modified: 03 Mar 2020 04:45
URI: http://eprints.mums.ac.ir/id/eprint/12963

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