A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration

De Vries, P. S. and Chasman, D. I. and Sabater-Lleal, M. and Chen, M. H. and Huffman, J. E. and Steri, M. and Tang, W. and Teumer, A. and Marioni, R. E. and Grossmann, V. and Hottenga, J. J. and Trompet, S. and Müller-Nurasyid, M. and Zhao, J. H. and Brody, J. A. and Kleber, M. E. and Guo, X. and Wang, J. J. and Auer, P. L. and Attia, J. R. and Yanek, L. R. and Ahluwalia, T. S. and Lahti, J. and Venturini, C. and Tanaka, T. and Bielak, L. F. and Joshi, P. K. and Rocanin-Arjo, A. and Kolcic, I. and Navarro, P. and Rose, L. M. and Oldmeadow, C. and Riess, H. and Mazur, J. and Basu, S. and Goel, A. and Yang, Q. and Ghanbari, M. and Gonnekewillemsen, and Rumley, A. and Fiorillo, E. and De Craen, A. J. M. and Grotevendt, A. and Scott, R. and Taylor, K. D. and Delgado, G. E. and Yao, J. and Kifley, A. and Kooperberg, C. and Qayyum, R. and Lopez, L. and Berentzen, T. L. and Räikkönen, K. and Massimomangino, and Bandinelli, S. and Peyser, P. A. and Wild, S. and Trégouët, D. A. and Wright, A. F. and Marten, J. and Zemunik, T. and Morrison, A. C. and Sennblad, B. and Tofler, G. and De Maat, M. P. M. and De Geus, E. J. C. and Lowe, G. D. and Zoledziewska, M. and Sattar, N. and Binder, H. and Völker, U. and Waldenberger, M. and Khaw, K. T. and McKnight, B. and Huang, J. and Jenny, N. S. and Holliday, E. G. and Qi, L. and McEvoy, M. G. and Becker, D. M. and Starr, J. M. and Sarin, A. P. and Hysi, P. G. and Hernandez, D. G. and Jhun, M. A. and Campbell, H. and Hamsten, A. and Sarin, F. and McArdle, W. L. and Eline Slagboom, P. and Zeller, T. and Koenig, W. and Psaty, B. and Haritunians, T. and Liu, J. and Palotie, A. and Uitterlinden, A. G. and Stott, D. J. and Hofman, A. and Franco, O. H. and others, (2016) A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. Human Molecular Genetics, 25 (2). pp. 358-370.

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Abstract

Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels.We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ~120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indelswere examined.We identified 41 genome-wide significant fibrinogen loci; of which, 18were newly identified. Therewere no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3 of the variance in plasma fibrinogen concentration. © The Author 2015. Published by Oxford University Press.

Item Type: Article
Additional Information: Cited By :24 Export Date: 16 February 2020 CODEN: HMGEE Correspondence Address: Dehghan, A.; Department of Epidemiology, Erasmus MC, Wytemaweg 80, Netherlands; email: a.dehghan@erasmusmc.nl
Uncontrolled Keywords: fibrinogen interferon regulatory factor 1 Article European fibrinogen blood level gene frequency gene locus genetic association genetic variability genome haplotype map human indel mutation meta analysis priority journal single nucleotide polymorphism variance X chromosome adult aged Caucasian clinical trial female genetics genome-wide association study male middle aged multicenter study very elderly Aged, 80 and over European Continental Ancestry Group Genetic Loci Humans Polymorphism, Single Nucleotide
Subjects: QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 03 Mar 2020 04:48
Last Modified: 03 Mar 2020 04:48
URI: http://eprints.mums.ac.ir/id/eprint/12964

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