Evaluation of the diagnostic value of a Modified Liquid-Based Cytology using OralCDx ® Brush in early detection of oral potentially malignant lesions and oral cancer

Delavarian, Z. and Mohtasham, N. and Mosannen-Mozaffari, P. and Pakfetrat, A. and Shakeri, M. T. and Ghafoorian-Maddah, R. (2010) Evaluation of the diagnostic value of a Modified Liquid-Based Cytology using OralCDx ® Brush in early detection of oral potentially malignant lesions and oral cancer. Medicina Oral, Patologia Oral y Cirugia Bucal, 15 (5). e671-e676.

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Abstract

Objectives: To determine diagnostic value of modified Liquid Based Brush Biopsy technique. Study design: 26 oral premalignant and malignant lesions in 25 patients (12 females; 54.23±19.77 years and 13 males; 53.77±15.43 years) underwent Modified (Liquid Based) Brush Biopsy and scalpel biopsy simultaneously from the same area. Results: There were 16 positive and 10 negative brush biopsy results, with no inadequate readings. Histological findings were compatible with oral leukoplakia(n=5)with dysplasia, Oral lichen planus and lichenoid reaction(n=7) (with or without dysplasia)oral squamous cell carcinoma(n=11),verrucous carcinoma(n=1) and granular cell tumors(n=2). Sensitivity, specificity, positive predictive value, negative predictive value, positive diagnostic likelihood ratio(LR+) and negative diagnostic likelihood ratio(LR-) were 88.8,100,100 , 80, infinity and 0.11 respectively(no false positive results). Conclusion: It is the first attempt to do LBC (liquid based cytology) with a specialized oral brush. Our results show that modified technique is a useful tool for screening of oral premalignant and malignant lesions. © Medicina Oral S. L.

Item Type: Article
Additional Information: Cited By :24 Export Date: 16 February 2020 Correspondence Address: Mosannen-Mozaffari, P.; Department of Oral Medicine, Mashhad Dental School, Vakil Abad BLV, Mashhad Khorasane Razavi Province, Iran; email: Mosannenp@mums.ac.ir
Uncontrolled Keywords: Brush biopsy Diagnostic value Dysplasia Liquid-based cytology Oral cancer Precancerous conditions adult aged article biopsy technique cancer diagnosis clinical article cytopathology diagnostic accuracy early diagnosis female granular cell tumor human leukoplakia lichen planus lichenoid liquid based cytology male mouth cancer prediction and forecasting scalpel sensitivity and specificity squamous cell carcinoma tumor biopsy verrucous carcinoma Biopsy Early Detection of Cancer Humans Middle Aged Mouth Neoplasms Young Adult
Subjects: WU Dentistry. Oral surgery
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 03 Mar 2020 04:52
Last Modified: 03 Mar 2020 04:52
URI: http://eprints.mums.ac.ir/id/eprint/12966

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