Improvement of plasma adiponectin, leptin and C-reactive protein concentrations by orlistat: A systematic review and meta-analysis

Derosa, G. and Maffioli, P. and Sahebkar, A. (2016) Improvement of plasma adiponectin, leptin and C-reactive protein concentrations by orlistat: A systematic review and meta-analysis. British Journal of Clinical Pharmacology, 81 (5). pp. 819-834.

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Aims: To conduct a systematic review and meta-analysis of relevant randomized clinical trials (RCTs) to ascertain the effect size of orlistat in modulating plasma levels of adipokines, ghrelin and C-reactive protein (CRP). Methods: Medline, SCOPUS, Web of Science and Google Scholar databases were searched. A random-effects model and the generic inverse variance method were used for quantitative data synthesis. Heterogeneity was quantitatively assessed using I2 index. Sensitivity analyses were conducted using the one-study remove approach. Random-effects meta-regression was performed using unrestricted maximum likelihood method to evaluate the impact of duration of treatment, percentage change in body mass index (BMI) and baseline BMI values as potential confounders of the estimated effect size. Results: Meta-analysis suggested a significant increase in plasma levels of adiponectin weighted mean difference (WMD): 19.18%, 95% confidence interval (CI): 5.80, 32.57, p = 0.005 and significant reductions in plasma levels of leptin (WMD: -13.24%, 95% CI: -20.69, -5.78, p = 0.001) and CRP (WMD: -11.52%, 95% CI: -16.55, -6.49, p < 0.001) following treatment with orlistat. In meta-regression, changes in plasma concentrations of adiponectin, leptin and CRP were associated with duration of treatment, but not with either change in BMI or baseline BMI values. Conclusion: Orlistat is effective in increasing plasma concentrations of adiponectin and decreasing those of leptin and CRP. © 2015 The British Pharmacological Society.

Item Type: Article
Additional Information: Cited By :13 Export Date: 16 February 2020 CODEN: BCPHB Correspondence Address: Sahebkar, A.; Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, P.O. Box: 91779-48564, Iran; email:
Uncontrolled Keywords: adiponectin C reactive protein ghrelin leptin placebo resistin tetrahydrolipstatin ADIPOQ protein, human antiobesity agent GHRL protein, human lactone body mass body weight drug effect human hypertension impaired glucose tolerance insulin resistance meta analysis non insulin dependent diabetes mellitus nonalcoholic fatty liver obesity priority journal protein blood level quality control randomized controlled trial (topic) Review systematic review treatment duration treatment outcome treatment response blood drug effects metabolic syndrome X Anti-Obesity Agents C-Reactive Protein Humans Lactones Randomized Controlled Trials as Topic
Subjects: QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 03 Mar 2020 04:55
Last Modified: 03 Mar 2020 04:55

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