Association of Serum hs-CRP Levels With the Presence of Obesity, Diabetes Mellitus, and Other Cardiovascular Risk Factors

Ebrahimi, M. and Heidari-Bakavoli, A. R. and Shoeibi, S. and Mirhafez, S. R. and Moohebati, M. and Esmaily, H. and Ghazavi, H. and Saberi Karimian, M. and Parizadeh, S. M. R. and Mohammadi, M. and Mohaddes Ardabili, H. and Ferns, G. A. and Ghayour-Mobarhan, M. (2016) Association of Serum hs-CRP Levels With the Presence of Obesity, Diabetes Mellitus, and Other Cardiovascular Risk Factors. Journal of Clinical Laboratory Analysis, 30 (5). pp. 672-676.

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Abstract

Background: Diabetes mellitus remains one of the major health problems of the 21st century and is associated with comorbidities including obesity and metabolic abnormalities. The study was conducted to evaluate serum high-sensitivity C-reactive protein (hs-CRP) levels, as a marker of inflammation, in a large sample of Iranian population without a history of cardiovascular or inflammatory disease and cancer, and to relate this to fasting blood glucose (FBG) and the presence of diabetes mellitus. Methods: The study consisted of 7,762 subjects divided into four groups—nonobese/nondiabetic, obese/nondiabetic, nonobese/diabetic and obese/diabetic—based on the BMI classification and their FBG. Anthropometric characteristics were measured and blood was collected for the evaluation of fasted lipid profile, FBG and serum hs-CRP levels. Results: Several clinical and biochemical characteristics were significantly different among the four groups: FBG, P < 0.001; total cholesterol (TC), P < 0.001; and triglyceride (TG), P < 0.001. The subjects with a serum hs-CRP >3 mg/dl had higher TC (P < 0.001), low-density lipoprotein cholesterol (LDL-C, P < 0.001), TG (P < 0.001), fat percentage (P < 0.001), and systolic and diastolic blood pressure (P < 0.001) compared with subjects with a serum hs-CRP <3 mg/dl. Multivariate analysis showed FBG, LDL-C, and waist circumference (WC) associated with increased serum hs-CRP levels (P < 0.001). Conclusions: FBG, LDL-C, WC and gender are independently associated with serum hs-CRP concentrations. © 2016 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: Cited By :11 Export Date: 16 February 2020 CODEN: JCANE Correspondence Address: Ghayour-Mobarhan, M.; Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical SciencesIran; email: ghayourm@mums.ac.ir
Uncontrolled Keywords: anthropometric characteristics diabetes high-sensitivity C-reactive protein (hs-CRP) obesity C reactive protein cholesterol glucose lipid low density lipoprotein cholesterol triacylglycerol adult Article body mass cardiovascular risk cholesterol blood level controlled study diabetes mellitus diastolic blood pressure female glucose blood level human Iranian people lipid analysis major clinical study male protein blood level risk factor systolic blood pressure waist circumference
Subjects: WG Cardiovascular System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 02 Mar 2020 09:48
Last Modified: 02 Mar 2020 09:48
URI: http://eprints.mums.ac.ir/id/eprint/12971

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