Antidotal effects of curcumin against neurotoxic agents: An updated review

Farkhondeh, T. and Samarghandian, S. and Samini, F. (2016) Antidotal effects of curcumin against neurotoxic agents: An updated review. Asian Pacific Journal of Tropical Medicine, 9 (10). pp. 947-953.

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Curcumin (CUR), the main phenolic composition in turmeric, shows preventive effects in various diseases. CUR is commonly found in the Curcuma species and historically applied in herbal medicine. Numerous studies have indicated that CUR possesses protective effects against toxic agents in the various animal tissues including the brain. This study found that CUR may be effective in nervous system problems induced by neurotoxic agents. However, due to the lack of information on human, more investigations are needed to determine the efficacy of CUR as an antidote matter. The current study aimed to critically review the recent literature data from 2014 to 2016 that regarding the therapeutic aspects of CUR versus neurotoxic agents-induced brain damage and its involved mechanisms. © 2016 Hainan Medical University

Item Type: Article
Additional Information: Cited By :7 Export Date: 16 February 2020 Correspondence Address: Samarghandian, S.; Department of Basic Medical Sciences, Neyshabur University of Medical SciencesIran; email:
Uncontrolled Keywords: Antidote Antioxidant Curcumin Neurotoxic agents 1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine 3 nitropropionic acid acrylamide arsenic chloranil fluoride formaldehyde galactosamine neurotoxin nitroprusside sodium oxaliplatin pentetrazole rotenone sevoflurane streptozocin vincristine brain damage cognitive defect drug effect drug mechanism human lipid peroxidation meta analysis nerve cell neurotoxicity nonhuman oxidative stress Parkinson disease priority journal Review signal transduction systematic review
Subjects: WL Nervous system
QX Parasitology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 02 Mar 2020 10:58
Last Modified: 02 Mar 2020 10:58

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