Analysis of respiratory events in obstructive sleep apnea syndrome: Inter-relations and association to simple nocturnal features

Ghandeharioun, H. and Rezaeitalab, F. and Lotfi, R. (2016) Analysis of respiratory events in obstructive sleep apnea syndrome: Inter-relations and association to simple nocturnal features. Revista Portuguesa de Pneumologia, 22 (2). pp. 86-92.

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Objective: This study carefully evaluates the association of different respiration-related events to each other and to simple nocturnal features in obstructive sleep apnea-hypopnea syndrome (OSAS). The events include apneas, hypopneas, respiratory event-related arousals and snores. Methods: We conducted a statistical study on 158 adults who underwent polysomnography between July 2012 and May 2014. To monitor relevance, along with linear statistical strategies like analysis of variance and bootstrapping a correlation coefficient standard error, the non-linear method of mutual information is also applied to illuminate vague results of linear techniques. Results: Based on normalized mutual information weights (NMIW), indices of apnea are 1.3 times more relevant to AHI values than those of hypopnea. NMIW for the number of blood oxygen desaturation below 95 is considerable (0.531). The next relevant feature is "respiratory arousals index" with NMIW of 0.501. Snore indices (0.314), and BMI (0.203) take the next place. Based on NMIW values, snoring events are nearly one-third (29.9) more dependent to hypopneas than RERAs. Conclusion: 1. The more sever the OSAS is, the more frequently the apneic events happen. 2. The association of snore with hypopnea/RERA revealed which is routinely ignored in regression-based OSAS modeling. 3. The statistical dependencies of oximetry features potentially can lead to home-based screening of OSAS. 4. Poor ESS-AHI relevance in the database under study indicates its disability for the OSA diagnosis compared to oximetry. 5. Based on poor RERA-snore/ESS relevance, detailed history of the symptoms plus polysomnography is suggested for accurate diagnosis of RERAs. © 2015 Sociedade Portuguesa de Pneumologia.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 CODEN: RPPEC Correspondence Address: Lotfi, R.; Department of Electrical Engineering, Ferdowsi University of MashhadIran; email:
Uncontrolled Keywords: Analysis of variance Bootstrapping technique Mutual information Obstructive sleep apnea-hypopnea syndrome Polysomnography Respiratory events adult apnea arousal Article disease severity female human intermethod comparison major clinical study male oximetry oxygen desaturation respiratory arousal index respiratory function respiratory tract parameters sleep disordered breathing snoring complication cross-sectional study middle aged pathophysiology Respiration Disorders Cross-Sectional Studies Humans Sleep Apnea, Obstructive
Subjects: WF Respiratory System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 02 Mar 2020 09:26
Last Modified: 02 Mar 2020 09:26

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