Ghasemi, M. and Zendehbad, B. and Zabihi, H. and Hosseini, M. and Hadjzadeh, M. A. R. and Hayatdavoudi, P. (2016) Beneficial effect of leptin on spatial learning and memory in streptozotocin-induced diabetic rats. Balkan Medical Journal, 33 (1). pp. 102-107.
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Abstract
Background: Diabetes mellitus is a chronic disease which may be accompanied by cognitive impairments. The expression of the obesity gene (ob) is decreased in insulin-deficient diabetic animals and increased after the administration of insulin or leptin. Plasma leptin levels are reduced in the streptozotocin (STZ)-induced diabetic rats. Therefore, the deleterious effects of diabetes on memory may be due to the reduction of leptin. Aims: Investigate the effect of subcutaneous injection of leptin on spatial learning and memory in STZ-induced diabetic rats. Study Design: Animal experimentation. Methods: The rats were divided into three groups: 1- control, 2- diabetic, and 3- diabetic-leptin. Diabetes was induced in groups 2 and 3 by STZ injection (55 mg/kg) intraperitoneally (i.p). The animals received leptin (0.1 mg/kg) or saline subcutaneously (s.c) for 10 days before behavioral studies. Then, they were examined in the Morris water maze over 3 blocks after 3 days of the last injection of leptin. Results: The travelled path length and time spent to reach the platform significantly increased in the diabetic group (p<0.001) and decreased with leptin treatment (p<0.01 & p<0.001 respectively); also, a significant increase in path length and time was observed between the diabetic-leptin group and the diabetic group (p<0.01, p<0.001, respectively) in the probe test. Conclusion: Leptin can exert positive effects on memory impairments in diabetic rats. © 2016 Trakya University Faculty of Medicine.
Item Type: | Article |
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Additional Information: | Cited By :5 Export Date: 16 February 2020 Correspondence Address: Hayatdavoudi, P.; Department of Physiology, Neurocognitive Research Center, Mashhad University of Medical SciencesIran; email: hayatdp891@mums.ac.ir |
Uncontrolled Keywords: | Leptin Spatial memory Streptozotocin glucose streptozocin adult animal experiment animal model Article controlled study glucose blood level male Morris water maze test nonhuman rat spatial learning streptozotocin-induced diabetes mellitus swimming |
Subjects: | WL Nervous system |
Divisions: | Mashhad University of Medical Sciences |
Depositing User: | mr lib4 lib4 |
Date Deposited: | 02 Mar 2020 09:35 |
Last Modified: | 02 Mar 2020 09:35 |
URI: | http://eprints.mums.ac.ir/id/eprint/12999 |
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